Title :

Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific.

Author(s) :

Cissé, Ouma [Auteur]
Institut de médecine predictive et de recherche thérapeutique [IMPRT]
Vallet Colom, Isabelle [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Delahaye, Fabien [Auteur]
Albert Einstein College of Medicine [New York]
Dickes, Anne [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Montel, Valerie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Moitrot, Emmanuelle [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Breton, Christophe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
vieau, didier [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Laborie, Christine [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]

Journal title :

European journal of nutrition

Abbreviated title :

Eur J Nutr

Volume number :

58

Pages :

2411-2423

Publisher :

Springer Link

Publication date :

2018-08-30

ISSN :

1436-6215

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Poor maternal nutrition sensitises to the development of metabolic diseases and obesity in adulthood over several generations. The prevalence increases when offspring is fed with a high-fat (HF) diet after ...
Show more >OBJECTIVE: Poor maternal nutrition sensitises to the development of metabolic diseases and obesity in adulthood over several generations. The prevalence increases when offspring is fed with a high-fat (HF) diet after weaning. This study aims to determine whether such metabolic profiles can be transmitted to the second generation and even aggravated when the mothers were exposed to overnutrition, with attention to potential sex differences. METHODS: Pregnant Wistar rats were subjected to ad libitum (control) or 70% food-restricted diet (FR) during gestation (F0). At weaning, F1 females were allocated to three food protocols: (1) standard diet prior to and throughout gestation and lactation, (2) HF diet prior to and standard diet throughout gestation and lactation, and (3) HF diet prior to and throughout gestation and lactation. F2 offspring was studied between 16 and 32 weeks of age. RESULTS: FR-F2 offspring on standard diet showed normal adiposity and had no significant metabolic alterations in adulthood. Maternal HF diet resulted in sex-specific effects with metabolic disturbances more apparent in control offspring exposed to HF diet during gestation and lactation. Control offspring displayed glucose intolerance associated with insulin resistance in females. Female livers overexpressed lipogenesis genes and those of males the genes involved in lipid oxidation. Gene expression was significantly attenuated in the FR livers. Increased physical activity associated with elevated corticosterone levels was observed in FR females on standard diet and in all females from overnourished mothers. CONCLUSIONS: Maternal undernutrition during gestation (F0) improves the metabolic health of second-generation offspring with more beneficial effects in females.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Research team(s) :

Activité Physique, Muscle, Santé (APMS)

Submission date :

2019-09-24T10:01:18Z
2021-12-08T10:49:02Z