Titre :

An innovative and efficient method to synthesize meloxicam in one-step procedure with respect to the green chemistry

Auteur(s) :

Dufrénoy, Pierrick [Auteur]
Hautes Etudes d’Ingénieur [Lille] [HEI]
Lille Inflammation Research International Center - U 995 [LIRIC]
Unité de Recherche en Chimie Organique et Macromoléculaire [URCOM]
Ghinet, Alina [Auteur]
Hautes Etudes d’Ingénieur [Lille] [HEI]
Alexandru Ioan Cuza University of Iași = Universitatea Alexandru Ioan Cuza din Iași [UAIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hechelski, Marie [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Daïch, Adam [Auteur]
Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire [INC3M]
Unité de Recherche en Chimie Organique et Macromoléculaire [URCOM]
Waterlot, Christophe [Auteur correspondant]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]

Titre de la revue :

Journal of the Iranian Chemical Society

Pagination :

501-509

Éditeur :

Iranian Chemical Society

Date de publication :

2019

ISSN :

1735-207X

Mot(s)-clé(s) en anglais :

Meloxicam
Heterogeneous catalyst
Montmorillonite K10
Metrics
Green chemistry

Discipline(s) HAL :

Chimie

Résumé en anglais : [en]

An improved procedure for the synthesis of meloxicam drug (methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazol-2-amine-3-carboxylate 1,1-dioxide) was described in one-step using mainly impregnated montmorillonite K10 (MK10) with ...
Lire la suite >An improved procedure for the synthesis of meloxicam drug (methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazol-2-amine-3-carboxylate 1,1-dioxide) was described in one-step using mainly impregnated montmorillonite K10 (MK10) with ZnCl 2 as a heterogeneous catalyst. This innovative method was compared to the last described procedure employed in the manufacture of this anti-inflammatory drug by means of some metrics used in a first step of the evaluation process of the environmental impact of a chemical transformation. Apart from the yield, which was 90%, atom economy, waste, environmental factor, reaction mass efficiency and stoichiometric factor were calculated as 91.6%, 8.4%, 0, 8.1% and 1%, respectively. Interpretation of these metrics was given and highlighted the fact that the strategy used in the current study may be considered as an environmental-friendly and sustainable method that fits well in the green chemistry concepts. © 2018, Iranian Chemical Society.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515

Source :

Harvested from HAL

Date de dépôt :

2025-02-26T12:57:38Z