Titre :

Anti-GAD Antibodies as an Etiology of Cerebral Cortical Encephalitis: 2 Case Reports.

Auteur(s) :

Lemarchant, Bruno [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Birzu, C. [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]
Couzyn, L. [Auteur]
Sorbonne Université - Faculté de Santé [CHU Pitié Salpétrière]
Department of Neurology
Rogeau, Stéphanie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Leclercq, D. [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Zephir, Helene [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Psimaras, D. [Auteur]
Institut du Cerveau = Paris Brain Institute [ICM]

Titre de la revue :

EUROPEAN JOURNAL OF NEUROLOGY
Eur J Neurol

Pagination :

e70096

Date de publication :

2025-03-03

ISSN :

1468-1331

Mot(s)-clé(s) en anglais :

anti- GAD antibodies
autoimmune encephalitis
CCE
cerebral cortical encephalitis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Introduction: Cerebral cortical encephalitis (CCE) has been recently described as an entity associated with anti-MOG antibod-ies and, in some cases, of anti- GABA A R encephalitis. No clear association with other antibodies ...
Lire la suite >Introduction: Cerebral cortical encephalitis (CCE) has been recently described as an entity associated with anti-MOG antibod-ies and, in some cases, of anti- GABA A R encephalitis. No clear association with other antibodies has been reported to date. Wedescribe two cases of patients presenting clinical and radiological features of diffuse cortical encephalitis associated with anti-GAD antibodies.Method: In two patients with CCE, screening for the presence of anti- GAD and other antibodies was performed, along with acomplete workup for alternative diagnoses.Results: Two patients showing clinical and radiological features of CCE were tested positive for anti- GAD antibodies. MRI scanrevealed multiple bilateral areas of cortico-subcortical FLAIR hyperintensities. They were both tested negative for anti-MOG,anti-NMDAr, and anti- GABA A R antibodies. An ovarian teratoma was discovered in patient 1. Clinical and radiological evolutionwas favorable in both patients after cumulated therapies in the acute phase.Discussion: CCE could be a new manifestation of anti- GAD antibodies, with distinct features compared to anti-MOG antibodiesrelated to CCE. We recommend screening for anti- GAD antibodies in the context of CCE, especially in case of atypical featuresfor MOG antibodies-associated disease (MOGAD).Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL