Title :

Poly(BETA-AMINO) ester based electrospun membranes with modulated degradation and release kinetics for potential wound dressing applications

Author(s) :

Ayaden, Liam [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

International Journal of Pharmaceutics

Volume number :

674

Pages :

125476

Publisher :

Elsevier

Publication date :

2025-04-15

ISSN :

0378-5173

HAL domain(s) :

Chimie/Matériaux
Chimie/Polymères
Sciences du Vivant [q-bio]

English abstract : [en]

Chronic wounds show no healing tendency over a period of up to 4 to 6 weeks despite any local treatment. These wounds present the persistence of the inflammatory stimulus and a high sensitivity to bacterial infection. ...
Show more >Chronic wounds show no healing tendency over a period of up to 4 to 6 weeks despite any local treatment. These wounds present the persistence of the inflammatory stimulus and a high sensitivity to bacterial infection. Engineering innovative wound dressings is key to facilitating the wound treatment, reducing healing time, and preventing recurrent infections. In this context, this project focused on the design of electrospun bioactive membrane based on Poly(Beta-amino)ester polymers (PBAEs) loaded with antibiotics (ciprofloxacin, CFX) for potential wound dressing applications. First, two PBAE macromers of different lengths were synthesized from the reaction of isobutylamine with two polyethylene glycol diacrylates (PEGDA). Both synthesized macromers exhibited opposite properties in terms of hydrophobicity (one is hydrophobic whereas the other one is hydrophilic) and crystallinity (amorphous or semi-crystalline). Then, both compounds were successfully electrospun with polyethylene oxide (PEO) and subjected to UV-curing to induce crosslinking of PBAE macromer. The membrane properties were similar in terms of hydrophilicity and crystallinity to the respective PBAE compounds, and these properties influenced degradation rates and drug release profiles. Finally, the antibacterial activity of the released drug was assessed to validate the bioactive profile of the membrane regarding bacterial infection.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2025-04-02T10:43:20Z
2025-04-03T17:17:24Z