Titre :

Poly(BETA-AMINO) ester based electrospun membranes with modulated degradation and release kinetics for potential wound dressing applications

Auteur(s) :

Ayaden, Liam [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Titre de la revue :

International Journal of Pharmaceutics

Nom court de la revue :

International Journal of Pharmaceutics

Numéro :

674

Pagination :

125476

Éditeur :

Elsevier

Date de publication :

2025-04-15

ISSN :

0378-5173

Discipline(s) HAL :

Chimie/Matériaux
Chimie/Polymères
Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Chronic wounds show no healing tendency over a period of up to 4 to 6 weeks despite any local treatment. These wounds present the persistence of the inflammatory stimulus and a high sensitivity to bacterial infection. ...
Lire la suite >Chronic wounds show no healing tendency over a period of up to 4 to 6 weeks despite any local treatment. These wounds present the persistence of the inflammatory stimulus and a high sensitivity to bacterial infection. Engineering innovative wound dressings is key to facilitating the wound treatment, reducing healing time, and preventing recurrent infections. In this context, this project focused on the design of electrospun bioactive membrane based on Poly(Beta-amino)ester polymers (PBAEs) loaded with antibiotics (ciprofloxacin, CFX) for potential wound dressing applications. First, two PBAE macromers of different lengths were synthesized from the reaction of isobutylamine with two polyethylene glycol diacrylates (PEGDA). Both synthesized macromers exhibited opposite properties in terms of hydrophobicity (one is hydrophobic whereas the other one is hydrophilic) and crystallinity (amorphous or semi-crystalline). Then, both compounds were successfully electrospun with polyethylene oxide (PEO) and subjected to UV-curing to induce crosslinking of PBAE macromer. The membrane properties were similar in terms of hydrophilicity and crystallinity to the respective PBAE compounds, and these properties influenced degradation rates and drug release profiles. Finally, the antibacterial activity of the released drug was assessed to validate the bioactive profile of the membrane regarding bacterial infection.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Ingénierie des Systèmes Polymères

Date de dépôt :

2025-04-02T10:43:20Z
2025-04-03T17:17:24Z