Title :

Illumination profile characterization of a light device for the dosimetry of intra-pleural photodynamic therapy for mesothelioma

Author(s) :

Munck, Camille [Auteur]
Mordon, Serge [Auteur]
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Betrouni, Nacim [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171

Journal title :

Photodiagnosis and photodynamic therapy

Abbreviated title :

Photodiagnosis Photodyn. Ther.

Volume number :

16

Pages :

23-26

Publication date :

2016-12-01

ISSN :

1572-1000

English keyword(s) :

Light device
Intrapleural photodynamic therapy
Dosimetry
Illumination profile
Mesh:Radiotherapy Dosage
Mesh:Radiometry/methods*
Mesh:Pleural Neoplasms/drug therapy*
Mesh:Photochemotherapy/methods
Mesh:Photochemotherapy/instrumentation*
Mesh:Mesothelioma/drug therapy*
Mesh:Lighting/methods
Mesh:Dose-Response Relationship
Mesh:Drug
Mesh:Dose-Response Relationship
Mesh:Radiation
Mesh:Drug Therapy
Mesh:Combination/methods
Mesh:Light
Mesh:Lighting/instrumentation*
Mesh:Equipment Design
Mesh:Equipment Failure Analysis
Mesh:Humans

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light ...
Show more >BACKGROUND: Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light around the light applicator could be the first step towards optimizing dosimetry. Here we propose a characterization method of the illumination profile of a specific light device. METHODS: The light wand, made of a cylindrical diffuser located inside an endotracheal tube, was fixed in a tank filled with dilute 0.01% intralipid. Light dosimetry was performed around the tip of the wand using two complementary methods: direct measurements of light power with an isotropic probe and measurements of light distribution characterization. RESULTS: Dosimetry with the isotropic probe showed an ellipse-shaped illumination. An optimized effective attenuation coefficient was deduced. Combined with the spatial representation, a theoretical illumination profile was established with iso-surfaces of fluence rate, defining a gradient light dose according to the distance from the diffuser. CONCLUSIONS: A theoretical illumination profile of a light device was established and could be part of an intra-operative dosimetry system to improve light delivery during intrapleural PDT.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
• Troubles cognitifs dégénératifs et vasculaires - U1171

Submission date :

2019-11-27T13:01:52Z