Title :

Apathy as a feature of prodromal alzheimer's disease: an fdg-pet adni study

Author(s) :

Delrieu, Julien [Auteur]
Desmidt, Thomas [Auteur]
Camus, Vincent [Auteur]
Sourdet, Sandrine [Auteur]
Boutoleau-Bretonniere, Claire [Auteur]
Mullin, Emmanuel [Auteur]
Vellas, Bruno [Auteur]
Payoux, Pierre [Auteur]
Lebouvier, Thibaud [Auteur]

Journal title :

International journal of geriatric psychiatry

Abbreviated title :

Int. J. Geriatr. Psychiatr.

Volume number :

30

Pages :

470-477

Publication date :

2015-05-01

ISSN :

0885-6230

English keyword(s) :

Alzheimer''s disease neuroimaging initiative (ADNI)
Alzheimer''s disease
biomarker
FDG-PET
apathy
mild cognitive impairment

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: The goal of this study is to evaluate brain metabolism in mild cognitive impairment (MCI) patients with and without apathy (as determined by the Neuropsychiatric Inventory Questionnaire). METHODS: Baseline data ...
Show more >OBJECTIVE: The goal of this study is to evaluate brain metabolism in mild cognitive impairment (MCI) patients with and without apathy (as determined by the Neuropsychiatric Inventory Questionnaire). METHODS: Baseline data from 65 MCI participants (11 with apathy and 54 without) from the Alzheimer's Disease (AD) Neuroimaging Initiative study were analyzed. All participants underwent a comprehensive cognitive and neuropsychiatric assessment, volumetric MRI and measures of cerebral glucose metabolism applying (18)F-fluorodeoxyglucose positron emission tomography at baseline. The presence of apathy at baseline was determined by the Neuropsychiatric Inventory Questionnaire. RESULTS: There was no difference between apathy and apathy-free MCI patients regarding cognitive assessment and neuropsychiatric measures when apathy-specific items were removed. Cerebrovascular disease load and cerebral atrophy were equivalent in both groups. Compared with the apathy-free MCI patients, MCI patients with apathy had significantly decreased metabolism in the posterior cingulate cortex. CONCLUSIONS: The presence of apathy in MCI patients is associated with AD-specific pattern of brain metabolic defect. These results could suggest that apathy belongs to the spectrum of prodromal AD symptoms.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:34:29Z