Title :

Influence of subthalamic deep-brain stimulation on cognitive action control in incentive context

Author(s) :

Houvenaghel, Jean-François [Auteur]
Duprez, Joan [Auteur]
Argaud, Soizic [Auteur]
Naudet, Florian [Auteur]
Dondaine, Thibaut [Auteur]
Robert, Gabriel [Auteur]
Drapier, Sophie [Auteur]
Haegelen, Claire [Auteur]
Jannin, Pierre [Auteur]
Drapier, Dominique [Auteur]
Verin, Marc [Auteur]
Sauleau, Paul [Auteur]

Journal title :

Neuropsychologia

Abbreviated title :

Neuropsychologia

Volume number :

91

Pages :

519-530

Publication date :

2016-10-01

ISSN :

0028-3932

English keyword(s) :

Deep brain stimulation
Parkinson''s disease
Simon Task
Cognitive control
Reward
Subthalamic nucleus

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Subthalamic nucleus deep-brain stimulation (STN-DBS) is an effective treatment in Parkinson's disease (PD), but can have cognitive side effects, such as increasing the difficulty of producing appropriate responses when a ...
Show more >Subthalamic nucleus deep-brain stimulation (STN-DBS) is an effective treatment in Parkinson's disease (PD), but can have cognitive side effects, such as increasing the difficulty of producing appropriate responses when a habitual but inappropriate responses represent strong alternatives. STN-DBS also appears to modulate representations of incentives such as monetary rewards. Furthermore, conflict resolution can be modulated by incentive context. We therefore used a rewarded Simon Task to assess the influence of promised rewards on cognitive action control in 50 patients with PD, half of whom were being treated with STN-DBS. Results were analyzed according to the activation-suppression model. We showed that STN-DBS (i) favored the expression of motor impulsivity, as measured with the Barratt Impulsiveness Scale, (ii) facilitated the expression of incentive actions as observed with a greater increase in speed according to promised reward in patients with versus without DBS and (iii) may increase impulsive action selection in an incentive context. In addition, analysis of subgroups of implanted patients suggested that those who exhibited the most impulsive action selection had the least severe disease. This may indicate that patients with less marked disease are more at risk of developing impulsivity postoperatively. Finally, in these patients, incentive context increased the difficulty of resolving conflict situations. As a whole, the current study revealed that in patients with PD, STN-DBS affects the cognitive processes involved in conflict resolution, reward processing and the influence of promised rewards on conflict resolution.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:37:28Z