Title :

Optimal achieved blood pressure in acute intracerebral hemorrhage: interact2

Author(s) :

Arima, Hisatomi [Auteur]
Heeley, Emma [Auteur]
Delcourt, Candice [Auteur]
Hirakawa, Yoichiro [Auteur]
Wang, Xia [Auteur]
Woodward, Mark [Auteur]
Robinson, Thompson [Auteur]
Stapf, Christian [Auteur]
Parsons, Mark W. [Auteur]
Lavados, Pablo M. [Auteur]
Huang, Yining [Auteur]
Wang, Jiguang [Auteur]
Chalmers, John [Auteur]
Anderson, Craig S. [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

84

Pages :

464-71

Publication date :

2015-02-03

ISSN :

1526-632X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). METHODS: INTERACT2 was ...
Show more >OBJECTIVE: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg. CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH. METHODS: This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:38:37Z