Title :

Early experience with new transcatheter mitral valve replacement

Author(s) :

Bapat, Vinayak [Auteur]
Rajagopal, Vivek [Auteur]
Meduri, Christopher [Auteur]
Farivar, R Saeid [Auteur]
Walton, Antony [Auteur]
Duffy, Stephen J. [Auteur]
Gooley, Robert [Auteur]
Almeida, Aubrey [Auteur]
Reardon, Michael J. [Auteur]
Kleiman, Neal S. [Auteur]
Spargias, Konstantinos [Auteur]
Pattakos, Stratis [Auteur]
Ng, Martin K. [Auteur]
Wilson, Michael [Auteur]
Adams, David H. [Auteur]
Leon, Martin B. [Auteur]
Mack, Michael J. [Auteur]
Chenoweth, Sharla [Auteur]
Sorajja, Paul [Auteur]

Journal title :

Journal of the American College of Cardiology

Abbreviated title :

J. Am. Coll. Cardiol.

Volume number :

71

Pages :

12-21

Publication date :

2018-01-02

ISSN :

0735-1097

English keyword(s) :

transcatheter mitral valve replacement
prosthesis
mitral valve regurgitation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Transcatheter mitral valve replacement (TMVR) is a potential therapy for patients with symptomatic, severe mitral regurgitation (MR). The feasibility of this therapy remains to be defined. The authors report their early ...
Show more >Transcatheter mitral valve replacement (TMVR) is a potential therapy for patients with symptomatic, severe mitral regurgitation (MR). The feasibility of this therapy remains to be defined. The authors report their early experience with TMVR using a new valve system. The valve is a self-expanding, nitinol valve with bovine pericardial leaflets that is placed using a transapical delivery system. Patients with symptomatic MR who were deemed high or extreme risk by the local heart teams were enrolled in a global pilot study at 14 sites (United States, Australia, and Europe). Fifty consecutively enrolled patients (mean age: 73 ± 9 years; 58.0% men; 84% secondary MR) underwent TMVR with the valve. The mean Society for Thoracic Surgery score was 6.4 ± 5.5%; 86% of patients were New York Heart Association functional class III or IV, and the mean left ventricular ejection fraction was 43 ± 12%. Device implant was successful in 48 patients with a median deployment time of 14 min (interquartile range: 12 to 17 min). The 30-day mortality was 14%, with no disabling strokes, or repeat interventions. Median follow-up was 173 days (interquartile range: 54 to 342 days). At latest follow-up, echocardiography confirmed mild or no residual MR in all patients who received implants. Improvements in symptom class (79% in New York Heart Association functional class I or II at follow-up; p < 0.0001 vs. baseline) and Minnesota Heart Failure Questionnaire scores (56.2 ± 26.8 vs. 31.7 ± 22.1; p = 0.011) were observed. TMVR with the valve was feasible in a study group at high or extreme risk for conventional mitral valve replacement. These results inform trial design of TMVR in lower-risk patients with severe mitral valve regurgitation (Evaluation of the Safety and Performance of the Twelve Intrepid Transcatheter Mitral Valve Replacement System in High Risk Patients with Severe, Symptomatic Mitral Regurgitation - The Twelve Intrepid TMVR Pilot Study; NCT02322840).Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:29:40Z