Title :

Stable prevalence of transmitted drug resistance mutations and increased circulation of non-b subtypes in antiretroviral-naive chronically hiv-infected patients in 2015/2016 in france

Author(s) :

Assoumou, Lambert [Auteur]
Bocket, Laurence [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Pallier, Coralie [Auteur]
Grude, Maxime [Auteur]
Ait-Namane, Rachid [Auteur]
Izopet, Jacques [Auteur]
Raymond, Stephanie [Auteur]
Charpentier, Charlotte [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Visseaux, Benoit [Auteur]
Wirden, Marc [Auteur]
Trabaud, Mary-Anne [Auteur]
Le Guillou-Guillemette, Helene [Auteur]
Allaoui, Chakib [Auteur]
Henquell, Cecile [Auteur]
Krivine, Anne [Auteur]
Dos Santos, Georges [Auteur]
Delamare, Catherine [Auteur]
Bouvier-Alias, Magali [Auteur]
Montes, Brigitte [Auteur]
Ferre, Virginie [Auteur]
De Monte, Anne [Auteur]
Signori-Schmuck, Anne [Auteur]
Maillard, Anne [Auteur]
Morand-Joubert, Laurence [Auteur]
Tumiotto, Camille [Auteur]
Fafi-Kremer, Samira [Auteur]
Amiel, Corinne [Auteur]
Barin, Francis [Auteur]
Marque-Juillet, Stephanie [Auteur]
Courdavault, Laurence [Auteur]
Vallet, Sophie [Auteur]
Beby-Defaux, Agnes [Auteur]
De Rougemont, Alexis [Auteur]
Fenaux, Honorine [Auteur]
Avettand-Fenoel, Véronique [Auteur]
Allardet-Servent, Annick [Auteur]
Plantier, Jean-Christophe [Auteur]
Peytavin, Gilles [Auteur]
Calvez, Vincent [Auteur]
Chaix, Marie-Laure [Auteur]
Descamps, Diane [Auteur]

Journal title :

The Journal of antimicrobial chemotherapy

Abbreviated title :

J. Antimicrob. Chemother.

Volume number :

74

Pages :

1417-1424

Publication date :

2019-02-11

ISSN :

1460-2091

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: We estimated the prevalence of transmitted-drug-resistance-associated mutations (TDRAMs) in antiretroviral-naive chronically HIV-1-infected patients. METHODS: TDRAMs were sought in samples from 660 diagnosed ...
Show more >OBJECTIVE: We estimated the prevalence of transmitted-drug-resistance-associated mutations (TDRAMs) in antiretroviral-naive chronically HIV-1-infected patients. METHODS: TDRAMs were sought in samples from 660 diagnosed HIV-1-infected individuals in 2015/2016 in 33 HIV clinical centres. Weighted analyses, considering the number of patients followed in each centre, were used to derive representative estimates of the percentage of individuals with TDRAMs. Results were compared with those of the 2010/2011 survey (n = 661) using the same methodology. RESULTS: At inclusion, median CD4 cell counts and plasma HIV-1 RNA were 394 and 350/mm3 (P = 0.056) and 4.6 and 4.6 log10 copies/mL (P = 0.360) in the 2010/2011 survey and the 2015/2016 survey, respectively. The frequency of non-B subtypes increased from 42.9% in 2010/2011 to 54.8% in 2015/2016 (P < 0.001), including 23.4% and 30.6% of CRF02_AG (P = 0.004). The prevalence of virus with protease or reverse-transcriptase TDRAMs was 9.0% (95% CI = 6.8-11.2) in 2010/2011 and 10.8% (95% CI = 8.4-13.2) in 2015/2016 (P = 0.269). No significant increase was observed in integrase inhibitor TDRAMs (6.7% versus 9.2%, P = 0.146). Multivariable analysis showed that men infected with the B subtype were the group with the highest risk of being infected with a resistant virus compared with others (adjusted OR = 2.2, 95% CI = 1.3-3.9). CONCLUSIONS: In France in 2015/2016, the overall prevalence of TDRAMs was 10.8% and stable compared with 9.0% in the 2010/2011 survey. Non-B subtypes dramatically increased after 2010. Men infected with B subtype were the group with the highest risk of being infected with a resistant virus, highlighting the need to re-emphasize safe sex messages.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2019-12-09T16:50:52Z
2024-02-23T09:52:27Z