Tcl1 expression patterns in waldenstrom ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Tcl1 expression patterns in waldenstrom macroglobulinemia
Auteur(s) :
Lemal, Richard [Auteur]
Bard-Sorel, Sandrine [Auteur]
Montrieul, Laura [Auteur]
Bay, Jacques-Olivier [Auteur]
Ravinet, Aurelie [Auteur]
Ledoux-Pilon, Albane [Auteur]
Cagnard, Nicolas [Auteur]
Bailly, Sébastien [Auteur]
Morel, Pierre [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Charlotte, Frédéric [Auteur]
Leleu, Xavier [Auteur]
Poulain, Stephanie [Auteur]
Dechelotte, Pierre J. [Auteur]
Hermine, O. [Auteur]
Leblond, Véronique [Auteur]
Tournilhac, Olivier [Auteur]
Guieze, Romain [Auteur]
Bard-Sorel, Sandrine [Auteur]
Montrieul, Laura [Auteur]
Bay, Jacques-Olivier [Auteur]
Ravinet, Aurelie [Auteur]
Ledoux-Pilon, Albane [Auteur]
Cagnard, Nicolas [Auteur]
Bailly, Sébastien [Auteur]
Morel, Pierre [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Charlotte, Frédéric [Auteur]
Leleu, Xavier [Auteur]
Poulain, Stephanie [Auteur]
Dechelotte, Pierre J. [Auteur]
Hermine, O. [Auteur]
Leblond, Véronique [Auteur]
Tournilhac, Olivier [Auteur]
Guieze, Romain [Auteur]
Titre de la revue :
Modern pathology . an official journal of the United States and Canadian Academy of Pathology, Inc
Nom court de la revue :
Mod. Pathol.
Numéro :
29
Pagination :
83-88
Date de publication :
2016-01-01
ISSN :
0893-3952
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as ...
Lire la suite >The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as multiple myeloma, classically do not express TCL1. Waldenström macroglobulinemia is a post-germinal center malignancy that is known to be similar to chronic lymphocytic leukemia in terms of its gene expression profile. TCL1 expression has not been so far assessed in Waldenström macroglobulinemia. Transcriptomic explorations show that TCL1A expression is linked to signaling pathways and biological functions that are known to be involved in Waldenström macroglobulinemia as well as to gene signatures of interest in B-cell malignancies. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenström macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact. TCL1 could have an oncogenic role in Waldenström macroglobulinemia, and deserves further exploration.Lire moins >
Lire la suite >The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as multiple myeloma, classically do not express TCL1. Waldenström macroglobulinemia is a post-germinal center malignancy that is known to be similar to chronic lymphocytic leukemia in terms of its gene expression profile. TCL1 expression has not been so far assessed in Waldenström macroglobulinemia. Transcriptomic explorations show that TCL1A expression is linked to signaling pathways and biological functions that are known to be involved in Waldenström macroglobulinemia as well as to gene signatures of interest in B-cell malignancies. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenström macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact. TCL1 could have an oncogenic role in Waldenström macroglobulinemia, and deserves further exploration.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Université de Lille
Université de Lille
Date de dépôt :
2019-12-09T16:52:56Z