Title :

Tcl1 expression patterns in waldenstrom macroglobulinemia

Author(s) :

Lemal, Richard [Auteur]
Bard-Sorel, Sandrine [Auteur]
Montrieul, Laura [Auteur]
Bay, Jacques-Olivier [Auteur]
Ravinet, Aurelie [Auteur]
Ledoux-Pilon, Albane [Auteur]
Cagnard, Nicolas [Auteur]
Bailly, Sébastien [Auteur]
Morel, Pierre [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Charlotte, Frédéric [Auteur]
Leleu, Xavier [Auteur]
Poulain, Stephanie [Auteur]
Dechelotte, Pierre J. [Auteur]
Hermine, O. [Auteur]
Leblond, Véronique [Auteur]
Tournilhac, Olivier [Auteur]
Guieze, Romain [Auteur]

Journal title :

Modern pathology . an official journal of the United States and Canadian Academy of Pathology, Inc

Abbreviated title :

Mod. Pathol.

Volume number :

29

Pages :

83-88

Publication date :

2016-01-01

ISSN :

0893-3952

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as ...
Show more >The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as multiple myeloma, classically do not express TCL1. Waldenström macroglobulinemia is a post-germinal center malignancy that is known to be similar to chronic lymphocytic leukemia in terms of its gene expression profile. TCL1 expression has not been so far assessed in Waldenström macroglobulinemia. Transcriptomic explorations show that TCL1A expression is linked to signaling pathways and biological functions that are known to be involved in Waldenström macroglobulinemia as well as to gene signatures of interest in B-cell malignancies. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenström macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact. TCL1 could have an oncogenic role in Waldenström macroglobulinemia, and deserves further exploration.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T16:52:56Z