Placental complications and bronchopulmonary dysplasia: epipage-2 cohort study

Torchin, Heloise; Ancel, Pierre-Yves; Goffinet, François; Hascoet, Jean-Michel; Truffert, Patrick; Tran, Diep; Lebeaux, Cécile; Jarreau, Pierre-Henri

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1542/peds.2015-2163

PMID :

26908662

URL permanente :

http://hdl.handle.net/20.500.12210/17007

Titre :

Placental complications and bronchopulmonary dysplasia: epipage-2 cohort study

Auteur(s) :

Torchin, Heloise [Auteur]
Ancel, Pierre-Yves [Auteur]
Goffinet, François [Auteur]
Hascoet, Jean-Michel [Auteur]
Truffert, Patrick [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Tran, Diep [Auteur]
Lebeaux, Cécile [Auteur]
Jarreau, Pierre-Henri [Auteur]

Titre de la revue :

Pediatrics

Nom court de la revue :

Pediatrics

Numéro :

137

Date de publication :

2016-03-01

ISSN :

0031-4005

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants. METHODS: National prospective population-based cohort study including ...
Lire la suite >OBJECTIVE: To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants. METHODS: National prospective population-based cohort study including 2697 singletons born before 32 weeks' gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders. RESULTS: Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P < .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1-10.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5-5.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0-2.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1-8.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1-3.9). CONCLUSIONS: Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T16:53:26Z

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