Title :

Retrospective study of imported falciparum malaria in french paediatric intensive care units

Author(s) :

Lanneaux, Justine [Auteur]
Dauger, Stéphane [Auteur]
Pham, Luu-Ly [Auteur]
Naudin, Jerome [Auteur]
Faye, Albert [Auteur]
Gillet, Yves [Auteur]
Bosdure, Emmanuelle [Auteur]
Carbajal, Ricardo [Auteur]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Vialet, Renaud [Auteur]
Cheron, Gerard [Auteur]
Angoulvant, François [Auteur]

Journal title :

Archives of disease in childhood

Abbreviated title :

Arch. Dis. Child.

Volume number :

101

Pages :

1004-1009

Publication date :

2016-11-01

ISSN :

0003-9888

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: The World Health Organization (WHO) severity criteria for paediatric Plasmodium falciparum METHODS: Retrospective case-control study. METHODS: Eight French university hospitals, from 2006 to 2012. METHODS: ...
Show more >OBJECTIVE: The World Health Organization (WHO) severity criteria for paediatric Plasmodium falciparum METHODS: Retrospective case-control study. METHODS: Eight French university hospitals, from 2006 to 2012. METHODS: Children with Pf malaria admitted to paediatric intensive care units (cases: n=55) or paediatric emergency departments (controls: n=110). METHODS: Descriptive analysis of WHO severity criteria and major interventions (mechanical ventilation, blood transfusion, fluid challenge, treatment of cerebral oedema, renal replacement therapy). Thresholds were set by receiver operating characteristics curve analysis. RESULTS: Altered consciousness (71% vs 5%), shock (24% vs 1%), renal failure (20% vs 1%), anaemia <50 g/L (7% vs 2%), acidosis (38% vs 0%), bilirubin level >50 µmol/L (25% vs 8%) and parasitaemia >10% (30% vs 8%) were more frequent in cases (p<0.01). All these criteria were associated with major interventions (p<0.001). Respiratory distress (six cases), and hypoglycaemia (two cases) were infrequent. Thrombocytopenia <50 000/mm3 CONCLUSIONS: The WHO severity criteria for paediatric Pf malaria are relevant for countries without endemic malaria. The infrequent but severe complications also provide a timely reminder of the morbidity and mortality associated with this condition worldwide. In non-endemic countries haemoglobin <70 g/L and platelet count <50 000/mm3Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T16:53:47Z