Title :

Impact of latency duration on the prognosis of preterm infants after preterm premature rupture of membranes at 24 to 32 weeks' gestation: a national population-based cohort study

Author(s) :

Lorthe, Elsa [Auteur]
Ancel, Pierre-Yves [Auteur]
Torchin, Heloise [Auteur]
Kaminski, Monique [Auteur]
Langer, Bruno [Auteur]
Subtil, Damien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Sentilhes, Loic [Auteur]
Arnaud, Catherine [Auteur]
Carbonne, Bruno [Auteur]
Debillon, Thierry [Auteur]
Delorme, Pierre [Auteur]
D'ercole, Claude [Auteur]
Dreyfus, Michel [Auteur]
Lebeaux, Cécile [Auteur]
Galimard, Jacques-Emmanuel [Auteur]
Vayssiere, Christophe [Auteur]
Winer, Norbert [Auteur]
Foix-L'helias, Laurence [Auteur]
Goffinet, François [Auteur]
Kayem, Gilles [Auteur]

Journal title :

The Journal of pediatrics

Abbreviated title :

J. Pediatr.

Volume number :

182

Pages :

47-52

Publication date :

2017-03-01

ISSN :

0022-3476

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To assess the impact of latency duration on survival, survival without severe morbidity, and early-onset sepsis in infants born after preterm premature rupture of membranes (PPROM) at 24-32 weeks' gestation. This study was ...
Show more >To assess the impact of latency duration on survival, survival without severe morbidity, and early-onset sepsis in infants born after preterm premature rupture of membranes (PPROM) at 24-32 weeks' gestation. This study was based on the prospective national population-based Etude Épidémiologique sur les Petits Ȃges Gestationnels 2 cohort of preterm births and included 702 singletons delivered in France after PPROM at 24-32 weeks' gestation. Latency duration was defined as the time from spontaneous rupture of membranes to delivery, divided into 4 periods (12 hours to 2 days [reference], 3-7 days, 8-14 days, and >14 days). Multivariable logistic regression was used to assess the relationship between latency duration and survival, survival without severe morbidity at discharge, or early-onset sepsis. Latency duration ranged from 12 hours to 2 days (18%), 3-7 days (38%), 8-14 days (24%), and >14 days (20%). Rates of survival, survival without severe morbidity, and early-onset sepsis were 93.5% (95% CI 91.8-94.8), 85.4% (82.4-87.9), and 3.4% (2.0-5.7), respectively. A crude association found between prolonged latency duration and improved survival disappeared on adjusting for gestational age at birth (aOR 1.0 [reference], 1.6 [95% CI 0.8-3.2], 1.2 [0.5-2.9], and 1.0 [0.3-3.2] for latency durations from 12 hours to 2 days, 3-7 days, 8-14 days, and >14 days, respectively). Prolonged latency duration was not associated with survival without severe morbidity or early-onset sepsis. For a given gestational age at birth, prolonged latency duration after PPROM does not worsen neonatal prognosis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T16:54:31Z