Abstention or intervention for isolated ...
Document type :
Article dans une revue scientifique: Article original
PMID :
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Title :
Abstention or intervention for isolated hypotension in the first 3?days of life in extremely preterm infants: association with short-term outcomes in the epipage 2 cohort study
Author(s) :
Durrmeyer, Xavier [Auteur]
Marchand-Martin, Laetitia [Auteur]
Porcher, Raphael [Auteur]
Gascoin, Geraldine [Auteur]
Roze, Jean-Christophe [Auteur]
Storme, Laurent [Auteur]
Environnement Périnatal et Santé - EA 4489
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Favrais, Geraldine [Auteur]
Ancel, Pierre-Yves [Auteur]
Cambonie, Gilles [Auteur]
Marchand-Martin, Laetitia [Auteur]
Porcher, Raphael [Auteur]
Gascoin, Geraldine [Auteur]
Roze, Jean-Christophe [Auteur]
Storme, Laurent [Auteur]
Environnement Périnatal et Santé - EA 4489
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Favrais, Geraldine [Auteur]
Ancel, Pierre-Yves [Auteur]
Cambonie, Gilles [Auteur]
Journal title :
Archives of disease in childhood. Fetal and neonatal edition
Abbreviated title :
Arch. Dis. Child. Fetal Neonatal Ed.
Volume number :
102
Pages :
490-496
Publication date :
2017-11-01
ISSN :
1468-2052
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did ...
Show more >OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did not receive antihypotensive treatment. METHODS: Etude Epidémiologique sur les Petits Ages Gestationnels 2 (EPIPAGE 2) French national prospective population-based cohort study in 2011. METHODS: 60 neonatal intensive care units. METHODS: All infants with a minimum mean arterial blood pressure less than gestational age (in weeks) (minMAP<GA) within 72 hours of birth. Infants whose reason for receiving antihypotensive treatments was isolated hypotension only were compared with untreated hypotensive infants by propensity score matching. METHODS: Fluid bolus and/or inotropes and/or corticosteroids. The primary outcome was survival at hospital discharge without major morbidity, defined as any of necrotising enterocolitis, severe cerebral abnormalities, severe bronchopulmonary dysplasia or severe retinopathy of prematurity. RESULTS: Among the 1532 infants with available data, 662 had a minMAP<GA; 206 were treated for unknown or other reasons than isolated hypotension, 131 were treated for isolated hypotension only and 325 were untreated; 119 infants from each of these last two groups were matched. Treated infants had a significantly higher survival rate without major morbidity (61.3% vs 48.7%; OR, 1.67, 95% CI 1.00 to 2.78, p=0.049) and a lower rate of severe cerebral abnormalities (10.1% vs 26.5%, p=0.002). CONCLUSIONS: In this population, antihypotensive treatment was associated with improved short-term outcomes. Therapeutic abstention should be cautiously considered for early isolated hypotension in extremely premature infants.Show less >
Show more >OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did not receive antihypotensive treatment. METHODS: Etude Epidémiologique sur les Petits Ages Gestationnels 2 (EPIPAGE 2) French national prospective population-based cohort study in 2011. METHODS: 60 neonatal intensive care units. METHODS: All infants with a minimum mean arterial blood pressure less than gestational age (in weeks) (minMAP<GA) within 72 hours of birth. Infants whose reason for receiving antihypotensive treatments was isolated hypotension only were compared with untreated hypotensive infants by propensity score matching. METHODS: Fluid bolus and/or inotropes and/or corticosteroids. The primary outcome was survival at hospital discharge without major morbidity, defined as any of necrotising enterocolitis, severe cerebral abnormalities, severe bronchopulmonary dysplasia or severe retinopathy of prematurity. RESULTS: Among the 1532 infants with available data, 662 had a minMAP<GA; 206 were treated for unknown or other reasons than isolated hypotension, 131 were treated for isolated hypotension only and 325 were untreated; 119 infants from each of these last two groups were matched. Treated infants had a significantly higher survival rate without major morbidity (61.3% vs 48.7%; OR, 1.67, 95% CI 1.00 to 2.78, p=0.049) and a lower rate of severe cerebral abnormalities (10.1% vs 26.5%, p=0.002). CONCLUSIONS: In this population, antihypotensive treatment was associated with improved short-term outcomes. Therapeutic abstention should be cautiously considered for early isolated hypotension in extremely premature infants.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Collections :
Submission date :
2019-12-09T16:54:47Z