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Comparison of response evaluation criteria ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1016/j.ejca.2014.11.008
PMID :
25499439
Permalink :
http://hdl.handle.net/20.500.12210/17096
Title :
Comparison of response evaluation criteria in solid tumours and choi criteria for response evaluation in patients with advanced soft tissue sarcoma treated with trabectedin: a retrospective analysis
Author(s) :
Taieb, Sophie [Auteur]
Saada-Bouzid, Esma [Auteur]
Tresch-Bruneel, Emmanuelle [Auteur]
Ryckewaert, Thomas [Auteur]
Bompas, Emmanuelle [Auteur]
Italiano, Antoine [Auteur]
Guillemet, Cécile [Auteur]
Peugniez, Charlotte [Auteur]
Piperno-Neumann, Sophie [Auteur]
Thyss, Antoine [Auteur]
Maynou, Carlos [Auteur] refId
Clisant-Delaine, Stephanie [Auteur]
Penel, Nicolas [Auteur] refId
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Journal title :
European journal of cancer (Oxford, England . 1990)
Abbreviated title :
Eur. J. Cancer
Volume number :
51
Pages :
202-209
Publication date :
2015-01-01
ISSN :
0959-8049
English keyword(s) :
Trabectedin
Sarcoma
Response assessment
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: To assess the additional value of density measurement using contrast-enhancement sequences (Choi assessment) in a real-life cohort of adult soft tissue sarcoma patients treated with trabectedin. METHODS: ...
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BACKGROUND: To assess the additional value of density measurement using contrast-enhancement sequences (Choi assessment) in a real-life cohort of adult soft tissue sarcoma patients treated with trabectedin. METHODS: Eligibility criteria included adults (age ⩾18) treated between 01/2007 and 12/2011, with at least two trabectedin cycles after failure or intolerance to doxorubicin/ifosfamide. Baseline and first computed tomography (CT)-scans were centrally reviewed by an experienced radiologist. RESULTS: The retrospective cohort consists of 134 (73 female) patients treated with trabectedin 1.5 mg/m(2) given as a 24-h infusion every 3 weeks. Patients received a median of five trabectedin cycles (range: 2-33) and the main cause of discontinuation was progressive disease (PD) (n = 105, 78.4%). Response Evaluation Criteria in Solid Tumours (RECIST) assessment was feasible in 128 (95.5%) patients, with Choi assessment performed in 92 (68.7%) patients, generally due to inadequate sequences or exclusive lung metastases. Concordance between both methods was fair (Kappa = 0.290). We identified five patients with false PD (i.e. PD according to RECIST but stable disease/partial response as per Choi). Univariate analysis did not identify any predictive factors for false PD. Median overall survival (OS) of patients with PD as per RECIST but stable disease/partial response (SD/PR) according to Choi was better than for patients with PD according to both RECIST and Choi (14 months versus 8 months; p = 0.052). CONCLUSIONS: Choi assessment may identify patients with false PD who achieved improved efficacy outcomes, suggesting that trabectedin may delay tumour progression even in the case of non-dimensional response. Dual size and tumour density assessment may be more suitable to evaluate responses to trabectedin in sarcoma patients as well as to improve the decision-making strategies for the continuation of trabectedin therapy.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Collections :
  • METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Submission date :
2019-12-09T16:56:09Z
Université de Lille

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