Bevacizumab associated with chemotherapy ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Bevacizumab associated with chemotherapy for initially non-resectable liver metastases from colorectal cancer: a case-control study
Author(s) :
Alt, Marie [Auteur]
Truant, Stéphanie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Renaud-Vantroys, Thibaut [Auteur]
Sequier, Cedric [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
El Amrany, Mehdi [Auteur]
Turpin, Anthony [Auteur]
Makhloufi, Samira [Auteur]
Pruvot, Francois-Rene [Auteur]
Hebbar, Mohamed [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Truant, Stéphanie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Renaud-Vantroys, Thibaut [Auteur]
Sequier, Cedric [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
El Amrany, Mehdi [Auteur]
Turpin, Anthony [Auteur]
Makhloufi, Samira [Auteur]
Pruvot, Francois-Rene [Auteur]
Hebbar, Mohamed [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Journal title :
Anticancer research
Abbreviated title :
Anticancer Res.
Volume number :
36
Pages :
5551-5555
Publication date :
2016-10-01
ISSN :
0250-7005
English keyword(s) :
Bevacizumab
colorectal cancer
liver metastases
colorectal cancer
liver metastases
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The place of bevacizumab in therapy of patients with initially non-resectable liver metastases from colorectal cancer (CRC) remains debated. Bevacizumab may increase the efficacy of chemotherapy but it may also maintain ...
Show more >The place of bevacizumab in therapy of patients with initially non-resectable liver metastases from colorectal cancer (CRC) remains debated. Bevacizumab may increase the efficacy of chemotherapy but it may also maintain dormant micrometastases in a dormant state, eventually increasing the long-term likelihood of tumor relapse. The aim of this study was to explore this hypothesis. A retrospective case-control study was performed in patients with initially non-resectable CRC liver metastases. Metastases were rendered resectable after chemotherapy with (cases) or without (controls) bevacizumab. Cases and controls were matched for synchronicity, number and maximal size of metastases. The main objective was the disease-free survival (DFS). A total of 82 patients were enrolled (41 in each group). The median DFS was 12.0 months in the bevacizumab group, and 10.2 months in the group treated with chemotherapy alone (p=0.26). We observed no significant effect on DFS for bevacizumab when added to chemotherapy in patients with initially non-resectable liver metastases. Prospective trials on this issue are warranted.Show less >
Show more >The place of bevacizumab in therapy of patients with initially non-resectable liver metastases from colorectal cancer (CRC) remains debated. Bevacizumab may increase the efficacy of chemotherapy but it may also maintain dormant micrometastases in a dormant state, eventually increasing the long-term likelihood of tumor relapse. The aim of this study was to explore this hypothesis. A retrospective case-control study was performed in patients with initially non-resectable CRC liver metastases. Metastases were rendered resectable after chemotherapy with (cases) or without (controls) bevacizumab. Cases and controls were matched for synchronicity, number and maximal size of metastases. The main objective was the disease-free survival (DFS). A total of 82 patients were enrolled (41 in each group). The median DFS was 12.0 months in the bevacizumab group, and 10.2 months in the group treated with chemotherapy alone (p=0.26). We observed no significant effect on DFS for bevacizumab when added to chemotherapy in patients with initially non-resectable liver metastases. Prospective trials on this issue are warranted.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Submission date :
2019-12-09T18:15:35Z