Titre :

Successful reperfusion with mechanical thrombectomy is associated with reduced disability and mortality in patients with pretreatment diffusion-weighted imaging-alberta stroke program early computed tomography score <= 6

Auteur(s) :

Desilles, Jean-Philippe [Auteur]
Consoli, Arturo [Auteur]
Redjem, Hocine [Auteur]
Coskun, Oguzhan [Auteur]
Ciccio, Gabriele [Auteur]
Smajda, Stanislas [Auteur]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Preda, Cristian [Auteur]
Laboratoire Paul Painlevé - UMR 8524
Laboratoire Paul Painlevé - UMR 8524 [LPP]
Ruiz Guerrero, Clara [Auteur]
Decroix, Jean-Pierre [Auteur]
Rodesch, Georges [Auteur]
Mazighi, Mikael [Auteur]
Blanc, Raphael [Auteur]
Piotin, Michel [Auteur]
Lapergue, Bertrand [Auteur]

Titre de la revue :

Stroke

Nom court de la revue :

Stroke

Numéro :

48

Pagination :

963-969

Date de publication :

2017-04-01

ISSN :

0039-2499

Mot(s)-clé(s) en anglais :

reperfusion
thrombectomy
outcome
large ischemic lesion
ischemic stroke

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. ...
Lire la suite >In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented in the recent randomized mechanical thrombectomy trials. Our aim was to assess the impact of reperfusion in pretreatment DWI-ASPECTS ≤6 patients treated with mechanical thrombectomy. We analyzed data collected between January 2012 and August 2015 in a bicentric prospective clinical registry of consecutive acute ischemic stroke patients treated with mechanical thrombectomy. Every patient with a documented internal carotid artery or middle cerebral artery occlusion with pretreatment DWI-ASPECTS ≤6 was eligible for this study. The primary end point was a favorable outcome defined by a modified Rankin Scale score ≤2 at 90 days. Two hundred and eighteen patients with a DWI-ASPECTS ≤6 were included. Among them, 145 (66%) patients had successful reperfusion at the end of mechanical thrombectomy. Reperfused patients had an increased rate of favorable outcome (38.7% versus 17.4%; PPPPP Successful reperfusion is associated with reduced mortality and disability in patients with a pretreatment DWI-ASPECTS ≤6. Further data from randomized studies are needed, particularly in patients with DWI-ASPECTS <5.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T18:16:13Z