The ferroquine antimalarial conundrum: ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition
Author(s) :
Dubar, Faustine [Auteur]
Slomianny, Christian [Auteur]
Khalife, Jamal [Auteur]
Dive, Daniel [Auteur]
Kalamou, Hadidjatou [Auteur]
Guerardel, Yann [Auteur]
Grellier, Philippe [Auteur]
Biot, Christophe [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Slomianny, Christian [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Khalife, Jamal [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Dive, Daniel [Auteur]
Kalamou, Hadidjatou [Auteur]
Guerardel, Yann [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Grellier, Philippe [Auteur]
Biot, Christophe [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Journal title :
Angewandte Chemie (International ed. in English)
Abbreviated title :
Angew. Chem. Int. Ed. Engl.
Volume number :
52
Pages :
7690-7693
Publication date :
2013-07-22
ISSN :
1521-3773
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another ...
Show more >Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.Show less >
Show more >Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.Show less >
Language :
Anglais
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Institut Pasteur de Lille
CNRS
Inserm
Université de Lille
Institut Pasteur de Lille
Collections :
Research team(s) :
Glycobiologie structurale des interactions hôtes-pathogènes
Submission date :
2020-02-12T15:11:07Z