Title :

Sulfated glycosaminoglycans in protein aggregation diseases

Author(s) :

Nishitsuji, Kazuchika [Auteur]
Tokushima University
Uchimura, Kenji [Auteur]
Nagoya University

Journal title :

Glycoconjugate journal

Abbreviated title :

Glycoconj. J.

Volume number :

34

Pages :

453-466

Publication date :

2017

ISSN :

1573-4986

English keyword(s) :

Heparan sulfate
Protein Aggregates
Protein aggregation disease
Animals
Glycosaminoglycans
Disease
Humans
Cell Communication
Amyloidosis
Sulfates
Protein Aggregation, Pathological

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Protein aggregation diseases are characterized by intracellular or extracellular deposition of misfolded and aggregated proteins. These aggregated deposits contain multiple proteinaceous and non-protein components that are ...
Show more >Protein aggregation diseases are characterized by intracellular or extracellular deposition of misfolded and aggregated proteins. These aggregated deposits contain multiple proteinaceous and non-protein components that are thought to play critical roles in the etiology and pathogenesis of protein aggregation diseases in vivo. One of these components, the sulfated glycosaminoglycans (GAGs), includes heparan sulfate, chondroitin sulfate, and keratan sulfate. The sulfated GAGs are negatively charged heteropolysaccharides expressed in all mammalian tissues. Enzymatically generated structural patterns and the degree of sulfation in GAGs determine GAGs' specific interactions with their protein ligands. Here, we review the potential roles of the sulfated GAGs in the pathogenesis and progression of protein aggregation diseases from a perspective of their sulfation modification. We also discuss the possibility of sulfated GAGs as therapeutic targets for protein aggregation diseases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Autres travaux scientifiques

Submission date :

2020-02-12T15:11:32Z
2021-07-13T09:05:35Z