Bile Diversion in Roux-en-Y Gastric Bypass ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake
Author(s) :
Baud, Gregory [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Daoudi, Mehdi [Auteur]
Hubert, Thomas [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Raverdy, Violeta [Auteur]
Pigeyre, Marie [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Hervieux, Erik [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Devienne, Magalie [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Ghunaim, Mohamed [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Bonner, Caroline [Auteur]
Quenon, Audrey [Auteur]
Pigny, Pascal [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Klein, Andre [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Pattou KERR-CONTE, Julie [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Gmyr, Valery [Auteur]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Recherche translationnelle sur le diabète - U 1190 [RTD]
Daoudi, Mehdi [Auteur]
Hubert, Thomas [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Raverdy, Violeta [Auteur]
Pigeyre, Marie [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Hervieux, Erik [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Devienne, Magalie [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Ghunaim, Mohamed [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Bonner, Caroline [Auteur]
Quenon, Audrey [Auteur]
Pigny, Pascal [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Klein, Andre [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Pattou KERR-CONTE, Julie [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Gmyr, Valery [Auteur]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Journal title :
Cell Metabolism
Abbreviated title :
Cell Metab.
Volume number :
23
Pages :
547-553
Publication date :
2016-03-08
ISSN :
1932-7420
English keyword(s) :
Obesity
Gastric Bypass
Humans
Male
Glucose
Bile Acids and Salts
Intestinal Absorption
Sodium-Glucose Transport Proteins
Animals
Jejunum
Biological Transport
Sodium
Swine
Swine
Miniature
Female
Gastric Bypass
Humans
Male
Glucose
Bile Acids and Salts
Intestinal Absorption
Sodium-Glucose Transport Proteins
Animals
Jejunum
Biological Transport
Sodium
Swine
Swine
Miniature
Female
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Gastro-intestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, independent of weight loss. Although changes in intestinal bile trafficking have been shown to play a role, the underlying mechanisms ...
Show more >Gastro-intestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, independent of weight loss. Although changes in intestinal bile trafficking have been shown to play a role, the underlying mechanisms are unclear. We performed RYGB in minipigs and showed that the intestinal uptake of ingested glucose is blunted in the bile-deprived alimentary limb (AL). Glucose uptake in the AL was restored by the addition of bile, and this effect was abolished when active glucose intestinal transport was blocked with phlorizin. Sodium-glucose cotransporter 1 remained expressed in the AL, while intraluminal sodium content was markedly decreased. Adding sodium to the AL had the same effect as bile on glucose uptake. It also increased postprandial blood glucose response in conscious minipigs following RYGB. The decrease in intestinal uptake of glucose after RYGB was confirmed in humans. Our results demonstrate that bile diversion affects postprandial glucose metabolism by modulating sodium-glucose intestinal cotransport.Show less >
Show more >Gastro-intestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, independent of weight loss. Although changes in intestinal bile trafficking have been shown to play a role, the underlying mechanisms are unclear. We performed RYGB in minipigs and showed that the intestinal uptake of ingested glucose is blunted in the bile-deprived alimentary limb (AL). Glucose uptake in the AL was restored by the addition of bile, and this effect was abolished when active glucose intestinal transport was blocked with phlorizin. Sodium-glucose cotransporter 1 remained expressed in the AL, while intraluminal sodium content was markedly decreased. Adding sodium to the AL had the same effect as bile on glucose uptake. It also increased postprandial blood glucose response in conscious minipigs following RYGB. The decrease in intestinal uptake of glucose after RYGB was confirmed in humans. Our results demonstrate that bile diversion affects postprandial glucose metabolism by modulating sodium-glucose intestinal cotransport.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
CNRS
Université de Lille
CHU Lille
CNRS
Collections :
Research team(s) :
Mécanismes moléculaires de la N-glycosylation et pathologies associées
Submission date :
2020-02-12T15:12:02Z
2020-04-15T09:00:30Z
2020-04-22T08:32:57Z
2020-04-27T08:37:46Z
2020-04-15T09:00:30Z
2020-04-22T08:32:57Z
2020-04-27T08:37:46Z
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