Titre :

Salvage Stereotactic Body Radiation Therapy for Local Prostate Cancer Recurrence After Radiation Therapy A Retrospective Multicenter Study of the GETUG

Auteur(s) :

Pasquier, David [Auteur correspondant]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Martinage, Geoffrey [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Janoray, Guillaume [Auteur]
Université de Tours [UT]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Rojas, Damaris Patricia [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Zerini, Dario [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Goupy, Flora [Auteur]
CRLCC Eugène Marquis [CRLCC]
de Crevoisier, Renaud [Auteur]
CRLCC Eugène Marquis [CRLCC]
Laboratoire Traitement du Signal et de l'Image [LTSI]
Bogart, Emilie [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Calais, Gilles [Auteur]
Université de Tours [UT]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Toledano, Alain [Auteur]
Chauveinc, Laurent [Auteur]
Scher, Nathaniel [Auteur]
Bondiau, Pierre Yves [Auteur]
Université Côte d'Azur [UniCA]
Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] [UNICANCER/CAL]
Hannoun-Levi, Jean Michel [Auteur]
Université Côte d'Azur [UniCA]
Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] [UNICANCER/CAL]
Silva, Marlon [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Meyer, Emmanuel [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Nickers, Philippe [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lacornerie, Thomas [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Jereczek-Fossa, Barbara Alicja [Auteur]
Università degli Studi di Milano = University of Milan [UNIMI]
Lartigau, Eric [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]

Titre de la revue :

International Journal of Radiation Oncology, Biology, Physics

Pagination :

727-734

Éditeur :

Elsevier

Date de publication :

2019-11

ISSN :

0360-3016

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Ingénierie biomédicale

Résumé en anglais : [en]

Purpose: To assess the efficacy and safety of salvage stereotactic body radiation therapy (SBRT) in patients with biopsy-proven local prostate cancer recurrence after radiation therapy.Methods and materials: Between April ...
Lire la suite >Purpose: To assess the efficacy and safety of salvage stereotactic body radiation therapy (SBRT) in patients with biopsy-proven local prostate cancer recurrence after radiation therapy.Methods and materials: Between April 2010 and January 2017, 100 patients were included in 7 centers. Disease extension was assessed by pelvic multiparametric magnetic resonance imaging and choline positron emission tomography in 87% and 94% of patients, respectively. The median time interval between the 2 treatments was 7.5 years (range, 2-18). Median prostate-specific antigen at recurrence was 4.3 ng/mL (range, 2-38). Median SBRT dose was 36 Gy (range, 25-36.25) in 6 fractions (range, 5-6), every other day. Thirty-four percent of patients were treated by androgen deprivation therapy for a median duration of 12 months. Toxicity was assessed according to Common Terminology Criteria for Adverse Events version 4.03.Results: Median follow-up was 29.3 months (range, 4-91). Second biochemical recurrence-free survival rate at 3 years was 55% (95% confidence interval [CI], 42%-66%). The initial D'Amico group, time interval after first radiation therapy, and SBRT dose were prognostic factors of biochemical recurrence-free survival in multivariate analysis (P = .09, P = .025, P = .018, respectively). No patient developed acute gastrointestinal toxicity of grade >1; rates of acute genitourinary toxicity of grade 2 and 3 were 8% and 1%, respectively. The actuarial 3-year grade ≥2 genitourinary and gastrointestinal toxicity was 20.8% (95% CI, 13%-29%) and 1% (95% CI, 0.1%-5.1%), respectively. One patient presented with neuritis of grade 3.Conclusions: With a short follow-up, this study shows that salvage SBRT allows for encouraging control and acceptable toxicity. Further prospective studies are necessary to confirm these preliminary results and to determine late toxicity.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL