Title :

Safety profile of intracranial electrode implantation for video-EEG recordings in drug-resistant focal epilepsy.

Author(s) :

Mathon, Bertrand [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Clemenceau, Stéphane [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Hasboun, Dominique [Auteur]
Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS]
CHU Pitié-Salpêtrière [AP-HP]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Habert, Marie-Odile [Auteur]
Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie [UPMC]
Belaid, Hayat [Auteur]
Laboratory of Physics of Materials and Nanomaterials Applied at Environment [LaPhyMNE]
Nguyen-Michel, Vi-Huong [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Lambrecq, Virginie [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
CHU Pitié-Salpêtrière [AP-HP]
Navarro, Vincent [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Dupont, Sophie [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Baulac, Michel [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Cortex et Epilepsie [Paris]
CHU Pitié-Salpêtrière [AP-HP]
Cornu, Philippe [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Adam, Claude [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Cortex et Epilepsie [Paris]

Journal title :

Journal of Neurology

Pages :

2699-712

Publisher :

Springer Verlag

Publication date :

2015-11-30

ISSN :

0340-5354

HAL domain(s) :

Sciences de l'ingénieur [physics]/Traitement du signal et de l'image [eess.SP]
Informatique [cs]/Vision par ordinateur et reconnaissance de formes [cs.CV]
Informatique [cs]/Imagerie médicale
Informatique [cs]/Traitement des images [eess.IV]
Sciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie

English abstract : [en]

Invasive electroencephalography recordings with depth or subdural electrodes are necessary to identify the ictogenic area in some drug-resistant focal epilepsies. We aimed to analyze the safety profile of intracranial ...
Show more >Invasive electroencephalography recordings with depth or subdural electrodes are necessary to identify the ictogenic area in some drug-resistant focal epilepsies. We aimed to analyze the safety profile of intracranial electrode implantation in a tertiary center and the factors associated with its complications. We retrospectively examined complications in 163 intracranial procedures performed in adult patients. Implantation methods included oblique depth stereotactic approach (n = 128) and medial-temporal depth stereotactic approach in combination with subdural strip placement (n = 35). 1201 depth macroelectrodes, 59 bundles of microelectrodes (in 30 patients) and 148 subdural electrodes were implanted. Complications were classified as major (requiring treatment or leading to neurological impairment) or minor. The rate of overall complications was 4.9 % (n = 8), with 3.1 % (n = 5) of major complications, though no permanent morbidity or mortality was recorded. Infection occurred in 1.2 % and hemorrhage in 3.7 % of patients. One hemorrhage occurred for every 225 electrodes implanted (4.4 ‰). Microelectrodes were not responsible for any complications. Overall and hemorrhagic complications were significantly associated with MRI-negative cases (7.3 and 6.3 % versus 0 %, p = 0.04). We believe that intracranial electrode implantation has a favorable safety profile, without permanent deficit. These risks should be balanced with the benefits of invasive exploration prior to surgery. Furthermore, this study provides preliminary evidence regarding the safety of micro-macroelectrodes.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL