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Diversity of monomers in nonribosomal ...
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Document type :
Article dans une revue scientifique
DOI :
10.1128/JB.00315-10
PMID :
20693331
Title :
Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.
Author(s) :
Caboche, Ségolène [Auteur]
Laboratoire des Procédés Biologiques Génie Enzymatique et Microbien [PROBIOGEM]
Sequential Learning [SEQUOIA]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Leclere, Valerie [Auteur] refId
Laboratoire des Procédés Biologiques Génie Enzymatique et Microbien [PROBIOGEM]
Pupin, Maude [Auteur correspondant] refId
Sequential Learning [SEQUOIA]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Kucherov, Gregory [Auteur]
Sequential Learning [SEQUOIA]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Jacques, Philippe [Auteur]
Laboratoire des Procédés Biologiques Génie Enzymatique et Microbien [PROBIOGEM]
Journal title :
Journal of Bacteriology
Pages :
5143-50
Publisher :
American Society for Microbiology
Publication date :
2010-10
ISSN :
0021-9193
HAL domain(s) :
Informatique [cs]/Bio-informatique [q-bio.QM]
Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
English abstract : [en]
Nonribosomal peptides (NRPs) are molecules produced by microorganisms that have a broad spectrum of biological activities and pharmaceutical applications (e.g., antibiotic, immunomodulating, and antitumor activities). One ...
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Nonribosomal peptides (NRPs) are molecules produced by microorganisms that have a broad spectrum of biological activities and pharmaceutical applications (e.g., antibiotic, immunomodulating, and antitumor activities). One particularity of the NRPs is the biodiversity of their monomers, extending far beyond the 20 proteogenic amino acid residues. Norine, a comprehensive database of NRPs, allowed us to review for the first time the main characteristics of the NRPs and especially their monomer biodiversity. Our analysis highlighted a significant similarity relationship between NRPs synthesized by bacteria and those isolated from metazoa, especially from sponges, supporting the hypothesis that some NRPs isolated from sponges are actually synthesized by symbiotic bacteria rather than by the sponges themselves. A comparison of peptide monomeric compositions as a function of biological activity showed that some monomers are specific to a class of activities. An analysis of the monomer compositions of peptide products predicted from genomic information (metagenomics and high-throughput genome sequencing) or of new peptides detected by mass spectrometry analysis applied to a culture supernatant can provide indications of the origin of a peptide and/or its biological activity.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
  • Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
Source :
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