Title :

Anti-inflammatory properties of [i]Streptococcus salivarius[/i], a commensal bacterium of the oral cavity and digestive tract

Author(s) :

Kaci, Ghalia [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Goudercourt, Denise [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dennin, Véronique [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pot, Bruno [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dore, Joel [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Ehrlich, Stanislav [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Renault, Pierre [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Blottiere, Herve [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Daniel, Catherine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Delorme, Christine [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]

Journal title :

Applied and Environmental Microbiology

Pages :

928-934

Publisher :

American Society for Microbiology

Publication date :

2014

ISSN :

0099-2240

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. ...
Show more >Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential of S. salivarius was first evaluated in vitro on human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that live S. salivarius strains inhibited in vitro the activation of the NF-κB pathway on intestinal epithelial cells. We also demonstrate that the live S. salivarius JIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. These in vitro and in vivo anti-inflammatory properties were not found with heat-killed S. salivarius, suggesting a protective response exclusively with metabolically active bacteria.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Non spécifiée

Popular science :

Non

European Project :

Metagenomics of the Human Intestinal Tract

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL