Titre :

Host–microbe interactions in distal airways: relevance to chronic airway diseases

Auteur(s) :

Martin, Clémence [Auteur]
Département des maladies respiratoires [CHU Cochin]
Burgel, Pierre-Régis [Auteur]
Hôpital Cochin [AP-HP]
Lepage, Patricia [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Andréjak, Claire [Auteur]
CHU Amiens-Picardie
de Blic, Jacques [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Bourdin, Arnaud [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Brouard, Jacques [Auteur]
CHU Caen
Chanez, Pascal [Auteur]
Aix Marseille Université [AMU]
Dalphin, Jean-Charles [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Deslée, Gaetan [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Deschildre, Antoine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gosset, Philippe [Auteur]
Défense innée et inflammation
Touqui, Lhousseine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dusser, Daniel [Auteur]
Service de pneumologie [CHU Cochin]

Titre de la revue :

EUROPEAN RESPIRATORY REVIEW

Pagination :

78 - 91

Éditeur :

European Respiratory Society

Date de publication :

2015-02-28

ISSN :

0905-9180

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

This article is the summary of a workshop, which took place in November 2013, on the roles of microorganisms in chronic respiratory diseases. Until recently, it was assumed that lower airways were sterile in healthy ...
Lire la suite >This article is the summary of a workshop, which took place in November 2013, on the roles of microorganisms in chronic respiratory diseases. Until recently, it was assumed that lower airways were sterile in healthy individuals. However, it has long been acknowledged that microorganisms could be identified in distal airway secretions from patients with various respiratory diseases, including cystic fibrosis (CF) and non-CF bronchiectasis, chronic obstructive pulmonary disease, asthma and other chronic airway diseases (e.g. post-transplantation bronchiolitis obliterans). These microorganisms were sometimes considered as infectious agents that triggered host immune responses and contributed to disease onset and/or progression; alternatively, microorganisms were often considered as colonisers, which were considered unlikely to play roles in disease pathophysiology. These concepts were developed at a time when the identification of microorganisms relied on culture-based methods. Importantly, the majority of microorganisms cannot be cultured using conventional methods, and the use of novel culture-independent methods that rely on the identification of microorganism genomes has revealed that healthy distal airways display a complex flora called the airway microbiota. The present article reviews some aspects of current literature on host-microbe (mostly bacteria and viruses) interactions in healthy and diseased airways, with a special focus on distal airways.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL