Title :

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

Author(s) :

Pitt, Jonathan M. [Auteur]
Université Paris-Saclay
Immunologie des tumeurs et immunothérapie [UMR 1015]
Institut Gustave Roussy [IGR]
Vetizou, Marie [Auteur]
Université Paris-Saclay
Immunologie des tumeurs et immunothérapie [UMR 1015]
Institut Gustave Roussy [IGR]
Boneca, Ivo Gomperts [Auteur]
Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall
Lepage, Patricia [Auteur]
Université Paris-Saclay
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Chamaillard, Mathias [Auteur]
Institut Pasteur de Lille
Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Zitvogel, Laurence [Auteur]
Université Paris-Saclay
Immunologie des tumeurs et immunothérapie [UMR 1015]
Immunité et cancer [U932]
Centre d'Investigation Clinique en Biotherapie des cancers [CIC 1428 , CBT 507 ]
Institut Gustave Roussy [IGR]

Journal title :

Oncoimmunology

Pages :

np

Publisher :

Taylor & Francis

Publication date :

2017

ISSN :

2162-4011

English keyword(s) :

microbiome
T cell
Anti-CTLA-4
Bacteroides
cancer
ipilimumab
microbiota

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Although anticancer therapy with immune checkpoint blockers has seen unprecedented success, it fails to control neoplasia in most patients and often causes immune-related adverse events (irAEs). Our recent research shows ...
Show more >Although anticancer therapy with immune checkpoint blockers has seen unprecedented success, it fails to control neoplasia in most patients and often causes immune-related adverse events (irAEs). Our recent research shows the immunostimulatory and antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species of the gut microbiota, signifying novel approaches to improve such immunotherapies.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Non spécifiée

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL