Title :

Relationship between gender and survival in a real-life cohort of patients with COPD

Author(s) :

Zysman, Maéva [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Université de Lorraine [UL]
Burgel, Pierre-Régis [Auteur]
Hôpital Cochin [AP-HP]
Court-Fortune, Isabelle [Auteur]
Service de Pneumologie et Oncologie thoracique [CHU Saint-Etienne]
Brinchault-Rabin, Graziella [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Nesme-Meyer, Pascale [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Surpas, Pascale [Auteur]
Deslée, Gaetan [Auteur]
Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 [P3CELL]
Hôpital Maison Blanche
Perez, Thierry [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Université de Lille
Le Rouzic, Olivier [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Université de Lille
Jebrak, Gilles [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Chanez, Pascal [Auteur]
Paillasseur, Jean-Louis [Auteur]
Caillaud, Denis [Auteur]
CHU Clermont-Ferrand
Roche, Nicolas [Auteur]
Hôpital Cochin [AP-HP]

Journal title :

Respiratory Research

Pages :

191

Publisher :

BioMed Central

Publication date :

2019-12

ISSN :

1465-9921

English keyword(s) :

Chronic obstructive pulmonary disease
Gender differences
Survival

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Although COPD affects both men and women, its prevalence is increasing more rapidly in women.Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whetherthis ...
Show more >Background: Although COPD affects both men and women, its prevalence is increasing more rapidly in women.Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whetherthis translates into a different prognosis remains to be determined. Our aim was to assess whether the greater clinicalimpact of COPD in women was associated with differences in 3-year mortality rates.Methods: In the French Initiatives BPCO real-world cohort, 177 women were matched up to 458 menon age (within 5-year intervals) and FEV1 (within 5% predicted intervals). 3-year mortality rate and survival were analyzed. Univariate andmultivariate logistic regression analyses were performed.Results: For a given age and level of airflow obstruction, women with COPD had more severe dyspnea, lower BMI, andwere more likely to exhibit anxiety. Nevertheless, three-year mortality rate was comparable among men and women,respectively 11.2 and 10.8%. In a multivariate model, the only factors significantly associated with mortality were dyspneaand malnutrition but not gender.Conclusion: Although women with COPD experience higher levels of dyspnea and anxiety than men at comparablelevels of age and FEV1, these differences do not translate into variations in 3-year mortality rates.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL