Titre :

Prioritising outcomes for evaluating eosinophil-guided corticosteroid therapy among patients with acute COPD exacerbations requiring hospitalisation: a Delphi consensus study

Auteur(s) :

Suehs, Carey Meredith [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Zysman, Maéva [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Chenivesse, Cecile [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Burgel, Pierre-Régis [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Couturaud, F. [Auteur]
CIC Brest
Deslée, Gaetan [Auteur]
Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 [P3CELL]
Berger, Patrick [Auteur]
CIC Bordeaux
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Raherison, Chantal [Auteur]
Bordeaux population health [BPH]
Devouassoux, Gilles [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Université Claude Bernard Lyon 1 [UCBL]
Brousse, Christophe [Auteur]
Roche, Nicolas [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Molimard, Mathieu [Auteur]
Bordeaux population health [BPH]
Chinet, Thierry [Auteur]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Devillier, Philippe [Auteur]
Hôpital Foch [Suresnes]
Université Paris-Saclay
Chanez, Pascal [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Aix Marseille Université [AMU]
Kessler, Romain [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Didier, Alain [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Service Pneumologie et allergologie pédiatrique [CHU Toulouse]
Martinat, Yan [Auteur]
Le Rouzic, Olivier [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Bourdin, Arnaud [Auteur]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]

Titre de la revue :

BMJ Open

Pagination :

e035811

Éditeur :

BMJ Publishing Group

Date de publication :

2020

ISSN :

2044-6055

Mot(s)-clé(s) en anglais :

Therapeutics
Respiratory medicine (see thoracic medicine)
Chronic airways disease

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

Résumé en anglais : [en]

Objectives Presently, those outcomes that should be prioritised for chronic obstructive pulmonary disease (COPD) exacerbation studies remain unclear. In order to coordinate multicentre studies on eosinophilia-driven ...
Lire la suite >Objectives Presently, those outcomes that should be prioritised for chronic obstructive pulmonary disease (COPD) exacerbation studies remain unclear. In order to coordinate multicentre studies on eosinophilia-driven corticosteroid therapy for patients hospitalised for acute exacerbation of COPD (AECOPD), we aimed to find consensus among experts in the domain regarding the prioritisation of outcomes.Design A modified Delphi study was proposed to recognised COPD experts. Two brainstorming questionnaires were used to collect potential outcomes. Four subsequent rounds of questionnaires were used to rank items according to a six-point Likert scale for their importance in the protocol, as well as for being the primary outcome. Priority outcome criteria were predefined as those for which ≥70% of experts indicated that the outcome was essential for interpreting study results.Setting COPD exacerbation management in France.Participants 34 experts recommended by the French Language Pulmonology Society were invited to participate. Of the latter, 21 experts participated in brainstorming, and 19 participated in all four ranking rounds.Results 105 outcomes were ranked. Two achieved consensus as candidate primary outcomes: (1) treatment failure defined as death from any cause or the need for intubation and mechanical ventilation, readmission because of COPD or intensification of pharmacologic therapy, and (2) the time required to meet predefined discharge criteria. The 10 secondary priority outcomes included survival, time with no sign of improvement, episodes of hospitalisation, exacerbation, pneumonia, mechanical or non-invasive ventilation and oxygen use, as well as comorbidities during the initial hospitalisation.Conclusions This Delphi consensus project generated and prioritised a great many outcomes, documenting current expert views concerning a diversity of COPD endpoints. Among the latter, 12 reached consensus as priority outcomes for evaluating the efficacy of eosinophil-driven corticosteroid therapy in AECOPD inpatients.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL