Title :

Potential causes and consequences of gastrointestinal disorders during a SARS-CoV-2 infection

Author(s) :

Trottein, Francois [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Sokol, Harry [Auteur]
CHU Saint-Antoine [AP-HP]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Centre de Recherche Saint-Antoine [CRSA]

Journal title :

Cell Reports

Pages :

107915

Publisher :

Elsevier Inc

Publication date :

2020

ISSN :

2211-1247

English keyword(s) :

COVID-19
SARS-CoV-2
disease outcomes
gastrointestinal symptoms
gut microbiota
microbial dysbiosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Coronaviruses cause several human diseases, including severe acute respiratory syndrome. The global coronavirus disease 2019 (COVID-19) pandemic has become a huge threat to humans. Intensive research on the pathogenic ...
Show more >Coronaviruses cause several human diseases, including severe acute respiratory syndrome. The global coronavirus disease 2019 (COVID-19) pandemic has become a huge threat to humans. Intensive research on the pathogenic mechanisms used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed-notably to identify potential drug targets. Clinical studies of patients with COVID-19 have shown that gastrointestinal disorders appear to precede or follow the respiratory symptoms. Here, we review gastrointestinal disorders in patients with COVID-19, suggest hypothetical mechanisms leading to gut symptoms, and discuss the potential consequences of gastrointestinal disorders on the outcome of the disease. Lastly, we discuss the role of the gut microbiota during respiratory viral infections and suggest that targeting gut dysbiosis may help to control the pathogenesis of COVID-19.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Rôle de l'axe poumon/intestin/moelle osseuse et du microbiote au cours de la grippe

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL