Title :

Cancer: a disease at the crossroads of trade-offs

Author(s) :

Jacqueline, Camille [Auteur correspondant]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Biro, Peter A. [Auteur]
Deakin University [Burwood]
Beckmann, Christa [Auteur]
Deakin University [Burwood]
Møller, Anders Pape [Auteur]
Ecologie Systématique et Evolution [ESE]
Renaud, François [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Sorci, Gabriele [Auteur]
Biogéosciences [UMR 6282] [BGS]
Tasiemski, Aurélie [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Ujvari, Beata [Auteur]
Deakin University [Burwood]
Thomas, Frédéric [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]

Journal title :

Evolutionary Applications

Pages :

215-225

Publisher :

Blackwell

Publication date :

2017-03

ISSN :

1752-4563

English keyword(s) :

Cancer
Life‐history traits
Natural selection
Trade‐off

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Biodiversité/Evolution [q-bio.PE]
Sciences du Vivant [q-bio]/Génétique/Génétique des populations [q-bio.PE]

English abstract : [en]

Central to evolutionary theory is the idea that living organisms face phenotypic and/or genetic trade-offs when allocating resources to competing life-history demands, such as growth, survival, and reproduction. These ...
Show more >Central to evolutionary theory is the idea that living organisms face phenotypic and/or genetic trade-offs when allocating resources to competing life-history demands, such as growth, survival, and reproduction. These trade-offs are increasingly considered to be crucial to further our understanding of cancer. First, evidences suggest that neoplastic cells, as any living entities subject to natural selection, are governed by trade-offs such as between survival and proliferation. Second, selection might also have shaped trade-offs at the organismal level, especially regarding protective mechanisms against cancer. Cancer can also emerge as a consequence of additional trade-offs in organisms (e.g., eco-immunological trade-offs). Here, we review the wide range of trade-offs that occur at different scales and their relevance for understanding cancer dynamics. We also discuss how acknowledging these phenomena, in light of human evolutionary history, may suggest new guidelines for preventive and therapeutic strategies.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Evolution de la résistance naturelle au cancer : le paradoxe de Peto revisité

Comment :

11 pages

Collections :

• Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198

Source :

Harvested from HAL