Titre :

Clinical relevance of soluble HLA class I molecules in Waldenstrom Macroglobulinemia.

Auteur(s) :

Moreau, Anne-Sophie [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Sebti, Yasmine [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Duhamel, Alain [Auteur]
Service de Biostatistiques [CHRU Lille]
Roccaro, Aldo M. [Auteur]
Coiteux, Valérie [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Gastinne, Thomas [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Le Friec, Gaëlle [Auteur]
Burwick, Nicholas [Auteur]
Amiot, Laurence [Auteur]
Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes [GERHM]
Service d'hématologie clinique
Ho, Allen W. [Auteur]
Poulain, Stephanie [Auteur]
Hennache, Bernadette [Auteur]
Hunter, Zachary R. [Auteur]
Dessaint, Jean-Paul [Auteur]
Laboratoire d'Immunologie [EA 2686]
Ghobrial, Irene M. [Auteur]
Treon, Steven P. [Auteur]
Facon, Thierry [Auteur]
Hôpital Claude Huriez [Lille]
Institut Mondor de Recherche Biomédicale [IMRB]
Zorn, Emmanuel [Auteur]
Leleu, Xavier [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]

Titre de la revue :

European Journal of Haematology

Pagination :

503-9

Éditeur :

Wiley

Date de publication :

2008-06

ISSN :

0902-4441

Mot(s)-clé(s) en anglais :

Waldenstrom Macroglobulinemia
IgM-monoclonal gammopathy of undetermined significance
serum total soluble HLA-I molecule
serum HLA-Gs molecule

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Hématologie

Résumé en anglais : [en]

OBJECTIVES: Waldenstrom Macroglobulinemia (WM) is a B-cell neoplasm characterised by secretion of IgM by lymphoplasmacytic bone marrow cells and by cytopenias and hypogammaglobulinemia in a subset of patients. Beta-2 ...
Lire la suite >OBJECTIVES: Waldenstrom Macroglobulinemia (WM) is a B-cell neoplasm characterised by secretion of IgM by lymphoplasmacytic bone marrow cells and by cytopenias and hypogammaglobulinemia in a subset of patients. Beta-2 microglobulin (b2m) is a major prognostic factor in WM and the heavy chain of HLA class I molecules, which are known to have immunosuppressive properties and have been implicated in the pathogeny of several malignancies. METHODS: We assessed the serum levels of the total soluble HLA-I molecules and the HLA-Gs molecules in 105 patients with IgM-related disorders [WM (n = 42) and IgM MGUS (n = 63)], and compared the results to 41 healthy subjects. RESULTS: We found higher levels of HLA-Is in WM, compared to IgM MGUS and healthy donors. HLA-Gs levels were similar in WM and in IgM MGUS, but higher than in healthy donors. The association between HLA-Is at the cut-off of 1.8 microg/mL and known markers of poor prognosis was then evaluated among WM patients using univariate and multivariate methods. Based on this, high HLA-Is level was strongly associated with high serum beta2M level >3 mg/L [OR = 2, (CI 95% 1.1-5.7); P = 0.04], age > 65 yrs [OR = 1.5, (CI 95% 0.5-4.1), P = 0.06] and haemoglobin < or =11.5 g/dL [OR = 3.3, (CI 95% 1.2-9.7); P = 0.03]. High levels of serum HLA-Is were also found in patients with cryoglobulinemia, however irrespectively of WM or IgM-MGUS status. CONCLUSION: Together our results suggest a possible role for soluble MHC class I molecules in WM disease. Further investigations are necessary to further demonstrate the prognostic impact of soluble MHC class I molecules in Waldenstrom Macroglobulinemia.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL