Fibrates, glitazones, and peroxisome proliferator-activated receptors.

Lalloyer, Fanny; Staels, Bart

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1161/ATVBAHA.108.179689

PMID :

20393155

Titre :

Fibrates, glitazones, and peroxisome proliferator-activated receptors.

Auteur(s) :

Lalloyer, Fanny [Auteur]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur correspondant]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]

Titre de la revue :

Arteriosclerosis, Thrombosis, and Vascular Biology

Pagination :

894-9

Éditeur :

American Heart Association

Date de publication :

2010-05

ISSN :

1079-5642

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire

Résumé en anglais : [en]

Several decades ago, fibrates were approved for the treatment of dyslipidemia, whereas thiazolidinediones were screened in animal models to improve glucose homeostasis and were subsequently developed for the treatment of ...
Lire la suite >Several decades ago, fibrates were approved for the treatment of dyslipidemia, whereas thiazolidinediones were screened in animal models to improve glucose homeostasis and were subsequently developed for the treatment of type 2 diabetes mellitus. Relatively recently, these drugs were found to act via peroxisome proliferator-activated receptors, nuclear receptors that control lipid metabolism and glucose homeostasis. In this historical perspective, we discuss the history of discovery of the peroxisome proliferator-activated receptors, from the clinical development of their agonists to the subsequent discovery of these receptors and their mechanisms of action, to finally evoke possibilities of targeted pharmacology for future development of selective peroxisome proliferator-activated receptor modulators.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL

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