Effects of Ferrocenyl 4-(Imino)-1,4-Dihy ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry.
Auteur(s) :
Marchand, Guillaume [Auteur]
Wambang, Nathalie [Auteur]
Pellegrini, Sylvain [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Molinaro, Caroline [Auteur]
Martoriati, Alain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Bousquet, Till [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Markey, Angel [Auteur]
Lescuyer-Rousseau, Arlette [Auteur]
Bodart, Jean-Francois [Auteur]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Pelinski, Lydie [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Marin, Matthieu [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Wambang, Nathalie [Auteur]
Pellegrini, Sylvain [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Molinaro, Caroline [Auteur]
Martoriati, Alain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Bousquet, Till [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Markey, Angel [Auteur]
Lescuyer-Rousseau, Arlette [Auteur]
Bodart, Jean-Francois [Auteur]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Pelinski, Lydie [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Marin, Matthieu [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Titre de la revue :
International Journal of Molecular Sciences
Nom court de la revue :
Int J Mol Sci
Numéro :
21
Date de publication :
2020-04-26
ISSN :
1422-0067
Mot(s)-clé(s) en anglais :
Xenopus laevis
cell death
ferrocenyldihydroquinoline
metaphase II spindle
oocyte
cell death
ferrocenyldihydroquinoline
metaphase II spindle
oocyte
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ...
Lire la suite >oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoline compound exerted deleterious effects on oocyte survival after 48 h of incubation at 100 μM. Two ferrocenyl dihydroquinoline compounds had an inhibitory effect on the resumption of progesterone induced oocyte meiosis, compared to controls without ferrocenyl groups. In these inhibited oocytes, no MPF (Cdk1/cyclin B) activity was detected by western blot analysis as shown by the lack of phosphorylation of histone H3. The dephosphorylation of the inhibitory Y15 residue of Cdk1 occurred but cyclin B was degraded. Moreover, two apoptotic death markers, the active caspase 3 and the phosphorylated histone H2, were detected. Only 7-chloro-1-ferrocenylmethyl-4-(phenylylimino)-1,4-dihydroquinoline () did not show any toxicity and allowed the assembly of a histologically normal metaphase II meiotic spindle while inhibiting the proliferation of cancer cell lines with a low IC, suggesting that this compound appears suitable as an antimitotic agent.Lire moins >
Lire la suite >oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoline compound exerted deleterious effects on oocyte survival after 48 h of incubation at 100 μM. Two ferrocenyl dihydroquinoline compounds had an inhibitory effect on the resumption of progesterone induced oocyte meiosis, compared to controls without ferrocenyl groups. In these inhibited oocytes, no MPF (Cdk1/cyclin B) activity was detected by western blot analysis as shown by the lack of phosphorylation of histone H3. The dephosphorylation of the inhibitory Y15 residue of Cdk1 occurred but cyclin B was degraded. Moreover, two apoptotic death markers, the active caspase 3 and the phosphorylated histone H2, were detected. Only 7-chloro-1-ferrocenylmethyl-4-(phenylylimino)-1,4-dihydroquinoline () did not show any toxicity and allowed the assembly of a histologically normal metaphase II meiotic spindle while inhibiting the proliferation of cancer cell lines with a low IC, suggesting that this compound appears suitable as an antimitotic agent.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Régulation des signaux de division
Date de dépôt :
2021-01-26T13:17:42Z
Fichiers
- P20.27 Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis.pdf
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