Radiologically isolated syndrome: 10-year risk estimate of a clinical event

Lebrun-Frenay, Christine; Kantarci, Orhun; Siva, Aksel; Sormani, Maria P.; Pelletier, Daniel; Okuda, Darin T.

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1002/ana.25799

PMID :

32500558

URL permanente :

http://hdl.handle.net/20.500.12210/39829

Titre :

Radiologically isolated syndrome: 10-year risk estimate of a clinical event

Auteur(s) :

Lebrun-Frenay, Christine [Auteur]
Kantarci, Orhun [Auteur]
Siva, Aksel [Auteur]
Sormani, Maria P. [Auteur]
Pelletier, Daniel [Auteur]
Okuda, Darin T. [Auteur]

Titre de la revue :

Annals of neurology

Nom court de la revue :

Ann. Neurol.

Date de publication :

2020-06-04

ISSN :

1531-8249

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

We have previously identified male sex, younger age, and the presence of spinal cord lesions as independent factors that increase the 5-year risk for evolution from radiologically isolated syndrome (RIS) to multiple ...
Lire la suite >We have previously identified male sex, younger age, and the presence of spinal cord lesions as independent factors that increase the 5-year risk for evolution from radiologically isolated syndrome (RIS) to multiple sclerosis. Here, we investigate risk factors for the development of a clinical event using a 10-year, multinational, retrospectively identified RIS dataset. RIS subjects were identified according to 2009 RIS criteria and followed longitudinally as part of a worldwide cohort study. We analyzed data from 21 individual databases from 5 different countries. Associations between clinical and magnetic resonance imaging (MRI) characteristics and the risk of developing a first clinical event were determined using multivariate Cox regression models. Additional follow-up data were available in 277 of 451 RIS subjects (86% female). The mean age at RIS diagnosis was 37.2 years (range, 11-74 years), with a median clinical follow-up of 6.7 years. The cumulative probability of a first clinical event at 10 years was 51.2%. Age, positive cerebrospinal fluid for oligoclonal bands, infratentorial lesions on MRI, and spinal cord lesions, were baseline independent predictors associated with a subsequent clinical event. The presence of gadolinium-enhanced lesions during follow-up was also associated with the risk of a seminal event. The reason for MRI and gadolinium-enhancing lesions at baseline did not influence the risk of a subsequent clinical event. Approximately half of all individuals with RIS experience a first clinical event within 10 years of the index MRI. The identification of independent predictors of risk for symptom onset may guide education and clinical management of individuals with RIS. ANN NEUROL 2020;88:407-417.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Neuroinflammation & Multiple Sclerosis (NEMESIS)

Date de dépôt :

2021-06-23T11:42:09Z

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