Thiotepa-busulfan-fludarabine (tbf) ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Thiotepa-busulfan-fludarabine (tbf) conditioning regimen in patients undergoing allogeneic hematopoietic cell transplantation for myelofibrosis: an outcome analysis from the chronic malignancies working party of the ebmt
Author(s) :
Battipaglia, Giorgia [Auteur]
Mauff, Katya [Auteur]
Wendel, Lotus [Auteur]
Angelucci, Emanuele [Auteur]
Mohty, Mohamad [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Arcese, William [Auteur]
Santarone, Stella [Auteur]
Rubio, Marie-Thérèse [Auteur]
Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA]
Krger, Nicolaus [Auteur]
Fox, Maria Laura [Auteur]
Blaise, Didier [Auteur]
Institut Paoli-Calmettes [IPC]
Iori, Anna Paola [Auteur]
Fanin, Renato [Auteur]
Chalandon, Yves [Auteur]
Pioltelli, Pietro [Auteur]
Marotta, Giuseppe [Auteur]
Chiusolo, Patrizia [Auteur]
Sever, Matjaz [Auteur]
Solano, Carlos [Auteur]
Contentin, Nathalie [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
De Wreede, Liesbeth C. [Auteur]
Czerw, Tomasz [Auteur]
Hernandez-Boluda, Juan Carlos [Auteur]
Hayden, Patrick J. [Auteur]
Mclornan, Donal P. [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Mauff, Katya [Auteur]
Wendel, Lotus [Auteur]
Angelucci, Emanuele [Auteur]
Mohty, Mohamad [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Arcese, William [Auteur]
Santarone, Stella [Auteur]
Rubio, Marie-Thérèse [Auteur]
Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA]
Krger, Nicolaus [Auteur]
Fox, Maria Laura [Auteur]
Blaise, Didier [Auteur]
Institut Paoli-Calmettes [IPC]
Iori, Anna Paola [Auteur]
Fanin, Renato [Auteur]
Chalandon, Yves [Auteur]
Pioltelli, Pietro [Auteur]
Marotta, Giuseppe [Auteur]
Chiusolo, Patrizia [Auteur]
Sever, Matjaz [Auteur]
Solano, Carlos [Auteur]
Contentin, Nathalie [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
De Wreede, Liesbeth C. [Auteur]
Czerw, Tomasz [Auteur]
Hernandez-Boluda, Juan Carlos [Auteur]
Hayden, Patrick J. [Auteur]
Mclornan, Donal P. [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Journal title :
Bone Marrow Transplantation
Abbreviated title :
Bone Marrow Transplant
Volume number :
56
Pages :
1593–1602
Publication date :
2021-02-01
ISSN :
1476-5365
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative option in MF. There is no consensus on the optimal conditioning regimen. We report outcomes of 187 patients with MF transplanted between ...
Show more >Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative option in MF. There is no consensus on the optimal conditioning regimen. We report outcomes of 187 patients with MF transplanted between 2010 and 2017 conditioned with TBF. Median age was 58 years. Median interval from diagnosis to allo-HCT was 44 months. Donors were haploidentical (41%), unrelated (36%) or HLA-identical siblings (23%). Stem cell source was PB in 60%. Conditioning was myeloablative in 48% of cases. Antithymocyte globulin (ATG) was used in 41% of patients. At 100 days, neutrophil and platelet engraftment were 91% and 63% after a median of 21 and 34 days, respectively. Grade II-IV and III-IV acute GVHD occurred in 24% and 12%, while at 3 years, all grade chronic GVHD and chronic extensive GVHD had been diagnosed in 38% and 11%. At 3 years, OS, RFS and GRFS were 55%, 49% and 43%, respectively. RI and NRM were 17% and 33%. On multivariate analysis, poor KPS and the use of unrelated donors were associated with worse GRFS and a higher grade II-IV acute GVHD, respectively. Neither donor type nor intensity of the conditioning regimen influenced survival outcomes. TBF is a feasible conditioning regimen in allo-HCT for MF in all donor settings although longer term outcomes are required.Show less >
Show more >Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative option in MF. There is no consensus on the optimal conditioning regimen. We report outcomes of 187 patients with MF transplanted between 2010 and 2017 conditioned with TBF. Median age was 58 years. Median interval from diagnosis to allo-HCT was 44 months. Donors were haploidentical (41%), unrelated (36%) or HLA-identical siblings (23%). Stem cell source was PB in 60%. Conditioning was myeloablative in 48% of cases. Antithymocyte globulin (ATG) was used in 41% of patients. At 100 days, neutrophil and platelet engraftment were 91% and 63% after a median of 21 and 34 days, respectively. Grade II-IV and III-IV acute GVHD occurred in 24% and 12%, while at 3 years, all grade chronic GVHD and chronic extensive GVHD had been diagnosed in 38% and 11%. At 3 years, OS, RFS and GRFS were 55%, 49% and 43%, respectively. RI and NRM were 17% and 33%. On multivariate analysis, poor KPS and the use of unrelated donors were associated with worse GRFS and a higher grade II-IV acute GVHD, respectively. Neither donor type nor intensity of the conditioning regimen influenced survival outcomes. TBF is a feasible conditioning regimen in allo-HCT for MF in all donor settings although longer term outcomes are required.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2021-07-06T12:44:46Z
2024-01-23T14:21:48Z
2024-01-23T14:21:48Z