Analysis of risk factors for complications ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Analysis of risk factors for complications and adverse obstetrical outcomes in women with takayasu arteritis: a french retrospective study and literature review
Auteur(s) :
Abisror, Noemie [Auteur]
Mekinian, Arsene [Auteur]
Hachulla, Eric [Auteur]
Lambert, Marc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Morel, Nathalie [Auteur]
Chapelon, Catherine [Auteur]
Martis, Nihal [Auteur]
Fuzibet, Jean Gabriel [Auteur]
Belenotti, Pauline [Auteur]
Swiader, Laure [Auteur]
Dhote, Robin [Auteur]
Mouthon, Luc [Auteur]
Sarrot-Reynault, Francoise [Auteur]
Andre, Marc [Auteur]
Smail, Amar [Auteur]
Gauthier, Jean Baptiste [Auteur]
Cathebras, Pascal [Auteur]
Neel, Antoine [Auteur]
Vandergheynst, Frederic [Auteur]
Rondeau, Murielle [Auteur]
Fur, Alain [Auteur]
Renou, Frederic [Auteur]
Godeau, Bertrand [Auteur]
Devaux, Bruno [Auteur]
Veyssier-Belot, Catherine [Auteur]
Cacoub, Patrice [Auteur]
Pourrat, Olivier [Auteur]
Haroche, Julien [Auteur]
Maurier, Francois [Auteur]
Lahuna, Constance [Auteur]
Fain, Olivier [Auteur]
Guillevin, Loic [Auteur]
Le Guern, Véronique [Auteur]
Costedoat-Chalumeau, Nathalie [Auteur]
Mekinian, Arsene [Auteur]
Hachulla, Eric [Auteur]
Lambert, Marc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Morel, Nathalie [Auteur]
Chapelon, Catherine [Auteur]
Martis, Nihal [Auteur]
Fuzibet, Jean Gabriel [Auteur]
Belenotti, Pauline [Auteur]
Swiader, Laure [Auteur]
Dhote, Robin [Auteur]
Mouthon, Luc [Auteur]
Sarrot-Reynault, Francoise [Auteur]
Andre, Marc [Auteur]
Smail, Amar [Auteur]
Gauthier, Jean Baptiste [Auteur]
Cathebras, Pascal [Auteur]
Neel, Antoine [Auteur]
Vandergheynst, Frederic [Auteur]
Rondeau, Murielle [Auteur]
Fur, Alain [Auteur]
Renou, Frederic [Auteur]
Godeau, Bertrand [Auteur]
Devaux, Bruno [Auteur]
Veyssier-Belot, Catherine [Auteur]
Cacoub, Patrice [Auteur]
Pourrat, Olivier [Auteur]
Haroche, Julien [Auteur]
Maurier, Francois [Auteur]
Lahuna, Constance [Auteur]
Fain, Olivier [Auteur]
Guillevin, Loic [Auteur]
Le Guern, Véronique [Auteur]
Costedoat-Chalumeau, Nathalie [Auteur]
Titre de la revue :
Clinical rheumatology
Nom court de la revue :
Clin. Rheumatol.
Date de publication :
2020-03-23
ISSN :
1434-9949
Mot(s)-clé(s) :
Pregnancy
Outcome
Risk factors
Takayasu arteritis
Outcome
Risk factors
Takayasu arteritis
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVE: Takayasu arteritis (TAK) is a large vessel vasculitis affecting young women of childbearing age. The outcome of pregnancies in TAK patients, factors associated with maternal and foetal complications and adverse ...
Lire la suite >OBJECTIVE: Takayasu arteritis (TAK) is a large vessel vasculitis affecting young women of childbearing age. The outcome of pregnancies in TAK patients, factors associated with maternal and foetal complications and adverse outcomes were analysed. METHODS: All pregnancies in women with a TAK diagnosis were retrospectively included from 20 French hospitals providing care for TAK, until August 2015. RESULTS: The study consisted of 43 pregnancies in 33 women, including 29 with a pre-existing TAK diagnosis and 4 diagnosed during pregnancy. Complications were observed in 20 pregnancies (47%), including 35% with arterial hypertension (n = 15), 9% with pre-eclampsia (n = 4), 2% with HELLP syndrome (n = 1) and 14% with intrauterine growth restriction (IUGR, n = 6, leading in one case to a medically indicated termination of pregnancy). There were 42 live births (98%) at a median term of 38 [27-42] weeks gestation including 9 before 37 weeks (21%). The median birth weight was 2940 [610-4310] grams. Five children (12%) required transfer to a neonatal intensive care unit. One premature boy (27 weeks gestation) died after 2 days. Treatment during pregnancy included steroids (n = 25/43; 58%), azathioprine (n = 9/43; 21%) and infliximab (n = 1/43; 2%). The risk of developing arterial hypertension during pregnancy was associated with previous chronic arterial hypertension and with an infra-diaphragmatic vasculitis injury (P = 0.01 and P = 0.04, respectively). No correlation was reported between TAK activity and any of the obstetrical complications described in the study. CONCLUSIONS: This study showed a high rate of adverse obstetrical complications without significant impact on live birth rates. Pregnancy did not appear to influence TAK disease activity. Key Points • We observed a high rate of adverse obstetrical complications in women with Takayasu arteritis; however, the rate of live births was high. Pregnancy did not appear to influence TA disease activity.Lire moins >
Lire la suite >OBJECTIVE: Takayasu arteritis (TAK) is a large vessel vasculitis affecting young women of childbearing age. The outcome of pregnancies in TAK patients, factors associated with maternal and foetal complications and adverse outcomes were analysed. METHODS: All pregnancies in women with a TAK diagnosis were retrospectively included from 20 French hospitals providing care for TAK, until August 2015. RESULTS: The study consisted of 43 pregnancies in 33 women, including 29 with a pre-existing TAK diagnosis and 4 diagnosed during pregnancy. Complications were observed in 20 pregnancies (47%), including 35% with arterial hypertension (n = 15), 9% with pre-eclampsia (n = 4), 2% with HELLP syndrome (n = 1) and 14% with intrauterine growth restriction (IUGR, n = 6, leading in one case to a medically indicated termination of pregnancy). There were 42 live births (98%) at a median term of 38 [27-42] weeks gestation including 9 before 37 weeks (21%). The median birth weight was 2940 [610-4310] grams. Five children (12%) required transfer to a neonatal intensive care unit. One premature boy (27 weeks gestation) died after 2 days. Treatment during pregnancy included steroids (n = 25/43; 58%), azathioprine (n = 9/43; 21%) and infliximab (n = 1/43; 2%). The risk of developing arterial hypertension during pregnancy was associated with previous chronic arterial hypertension and with an infra-diaphragmatic vasculitis injury (P = 0.01 and P = 0.04, respectively). No correlation was reported between TAK activity and any of the obstetrical complications described in the study. CONCLUSIONS: This study showed a high rate of adverse obstetrical complications without significant impact on live birth rates. Pregnancy did not appear to influence TAK disease activity. Key Points • We observed a high rate of adverse obstetrical complications in women with Takayasu arteritis; however, the rate of live births was high. Pregnancy did not appear to influence TA disease activity.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Collections :
Date de dépôt :
2021-07-06T12:46:51Z