A planar microfabricated nanoelectrospray emitter tip based on a capillary slot

Le Gac, Séverine; Arscott, Steve; Rolando, Christian

Document type :

Compte-rendu et recension critique d'ouvrage

DOI :

10.1002/elps.200305664

Title :

A planar microfabricated nanoelectrospray emitter tip based on a capillary slot

Author(s) :

Le Gac, Séverine [Auteur]
Arscott, Steve [Auteur]

Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Rolando, Christian [Auteur]

Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]

Journal title :

Electrophoresis

Pages :

3640-3647

Publisher :

Wiley-VCH Verlag

Publication date :

2003-11

ISSN :

0173-0835

English keyword(s) :

Microfabricated emitter tip
Microfluids
Miniaturization
Nanoelectrospray ionization

HAL domain(s) :

Sciences de l'ingénieur [physics]

English abstract : [en]

We report on the fabrication and testing of planar nib-like structures for nanoelectrospray ionization-mass spectrometry (nanoESI-MS) applications. The micro-nib structures were fabricated on silicon substrates using the ...
Show more >We report on the fabrication and testing of planar nib-like structures for nanoelectrospray ionization-mass spectrometry (nanoESI-MS) applications. The micro-nib structures were fabricated on silicon substrates using the negative photoresist SU-8; they include capillary slots with widths of 8 and 16 μm. A suitable wafer cleaving step made the nib-like structures overhang the edge of a silicon substrate to provide a robust interface for nanoESI-MS applications; this freeing of the nib tip from the wafer surface created a point-like structure that is essential to establish an electrospray. The micro-nib sources were successfully tested on an LCQ Deca XP+ ion trap mass spectrometer using peptide samples at concentrations down to 1 μm. The high voltage was applied using a platinum wire inserted in the sample reservoir upstream to the capillary slot. A Taylor cone was clearly seen at the nib tip. The micro-nibs performed well at voltages as low as 0.8 kV; such performances are state-of-the-art with respect to current micromachined ESI-MS interfaces and are conditions comparable to those used for standard emitter tips. In addition, we clearly observed the influence of the micro-nib slot width on the ionization performances: the narrower the slot, the better the performances.Show less >

Language :

Anglais

Popular science :

Non

Collections :

Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Source :

Harvested from HAL

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