Title :

Autobiographical memory decline in Alzheimer's disease, a theoretical and clinical overview

Author(s) :

El Haj, Mohamad [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Antoine, Pascal [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Nandrino, Jean-Louis [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Kapogiannis, Dimitrios [Auteur]

Journal title :

Ageing Research Reviews - ARR

Abbreviated title :

Ageing Res. Rev.

Volume number :

23

Pages :

183-192

Publisher :

Elsevier

Publication date :

2015-09

ISSN :

1568-1637

English keyword(s) :

Alzheimer’ s disease
Autobiographical memory
Rehabilitation
Executive function
Hippocampus
Personal identity
Sense of self

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer's disease (AD), results in an ...
Show more >Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Decline of this ability, as observed in Alzheimer's disease (AD), results in an impaired sense of self and identity. In our model (AMAD: Autobiographical Memory in Alzheimer's Disease), we present a critical review of theories and findings regarding cognitive and neuroanatomical underpinnings of autobiographical memory and its decline in AD and highlight studies on its clinical rehabilitation. We propose that autobiographical recall in AD is mainly characterized by loss of associated episodic information, which leads to de-contextualization of autobiographical memories and a shift from reliving past events to a general sense of familiarity. This decline refers to retrograde, but also anterograde amnesia that affects newly acquired memories besides remote ones. One consequence of autobiographical memory decline in AD is decreased access to memories that shape self-consciousness, self-knowledge, and self-images, leading to a diminished sense of self and identity. The link between autobiographical decline and compromised sense of self in AD can also manifest itself as low correspondence and coherence between past memories and current goals and beliefs. By linking cognitive, neuroanatomical, and clinical aspects of autobiographical decline in AD, our review provides a theoretical foundation, which may lead to better rehabilitation strategies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Dynamique Émotionnelle et Pathologies (DEEP)

Submission date :

2019-02-13T14:50:42Z
2019-11-26T15:45:28Z
2021-01-25T14:55:27Z