Deviations in cortex sulcation associated with visual hallucinations in schizophrenia

Cachia, A.; Amad, Ali; Brunelin, J.; Krebs, M.-O.; Plaze, M.; Thomas, Pierre; Jardri, Renaud

Document type :

Article dans une revue scientifique

DOI :

10.1038/mp.2014.140

PMID :

25349166

Permalink :

http://hdl.handle.net/20.500.12210/4227

Title :

Deviations in cortex sulcation associated with visual hallucinations in schizophrenia

Author(s) :

Cachia, A. [Auteur]
Amad, Ali [Auteur]

Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Brunelin, J. [Auteur]
Krebs, M.-O. [Auteur]
Plaze, M. [Auteur]
Thomas, Pierre [Auteur]

Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Jardri, Renaud [Auteur]

Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]

Journal title :

Molecular psychiatry

Abbreviated title :

Mol. Psychiatry

Volume number :

Pages :

1101-1107

Publication date :

2015-09

ISSN :

1476-5578

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Hallucinations, and auditory hallucinations (AH) in particular, constitute the most typical and disabling schizophrenia symptoms. Although visual hallucinations (VH) have been largely neglected in psychiatric disorders, a ...
Show more >Hallucinations, and auditory hallucinations (AH) in particular, constitute the most typical and disabling schizophrenia symptoms. Although visual hallucinations (VH) have been largely neglected in psychiatric disorders, a recent review reported a 27% mean prevalence of VH in schizophrenia patients. The pathophysiology underlying VH in schizophrenia remains elusive. Several schizophrenia studies reported a significant effect of age on VH; therefore, we tested the hypothesis that the neurodevelopmental model of schizophrenia may explain VH occurrence. We analyzed cortex sulcation, a marker of brain development, in healthy controls (HCs) and two subgroups of carefully selected schizophrenia patients suffering from hallucinations: patients with only AH (that is, patients who never reported VH) and patients with audio-visual hallucinations (A+VH). Different cortical sulcation and left-right sulcal asymmetry were found between A+VH and AH patients, with decreased sulcation in both A+VH and AH patients in comparison with the HCs. Although a specific association between VH and neurodegenerative mechanisms, for example, in Body-Lewy Dementia or Parkinson's Disease, has previously been reported in the literature, the current study provides the first neuroimaging evidence of an association between VH and neurodevelopmental mechanisms.Show less >

Language :

Anglais

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Psychiatrie & Croyance (PsyCHIC)

Submission date :

2019-02-13T14:50:48Z

Version	Link	Modification date
2	20.500.12210/4227	2019-12-17T16:36:30Z
1	20.500.12210/4227.1*	2019-02-13T14:50:48Z

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