Use of aspirin and bleeding-related complications after hepatic resection.

Gelli, M; Allard M, A; Farges, O; Paugam-Burtz, C; Mabrut J, Y; Regimbeau J, M; Vibert, Eric; Boleslawski, Emmanuel

Type de document :

Article dans une revue scientifique

DOI :

10.1002/bjs.10697

PMID :

29412449

URL permanente :

http://hdl.handle.net/20.500.12210/4314

Titre :

Use of aspirin and bleeding-related complications after hepatic resection.

Auteur(s) :

Gelli, M [Auteur]
Allard M, A [Auteur]
Farges, O [Auteur]
Paugam-Burtz, C [Auteur]
Mabrut J, Y [Auteur]
Regimbeau J, M [Auteur]
Vibert, Eric [Auteur]
Boleslawski, Emmanuel [Auteur]

Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161
Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]

Titre de la revue :

The British journal of surgery

Nom court de la revue :

Br J Surg

Date de publication :

2018

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: The operative risk of hepatectomy under antiplatelet therapy is unknown. This study sought to assess the outcomes of elective hepatectomy performed with or without aspirin continuation in a well balanced matched ...
Lire la suite >BACKGROUND: The operative risk of hepatectomy under antiplatelet therapy is unknown. This study sought to assess the outcomes of elective hepatectomy performed with or without aspirin continuation in a well balanced matched cohort. METHODS: Data were retrieved from a multicentre prospective observational study. Aspirin and control groups were compared by non-standardized methods and by propensity score (PS) matching analysis. The main outcome was severe (Dindo-Clavien grade IIIa or more) haemorrhage. Other outcomes analysed were intraoperative transfusion, overall haemorrhage, major morbidity, comprehensive complication index (CCI) score, thromboembolic complications, ischaemic complications and mortality. RESULTS: Before matching, there were 118 patients in the aspirin group and 1685 in the control group. ASA fitness grade, cardiovascular disease, previous history of angina pectoris, angioplasty, diabetes, use of vitamin K antagonists, cirrhosis and type of hepatectomy were significantly different between the groups. After PS matching, 108 patients were included in each group. There were no statistically significant differences between the aspirin and control groups in severe haemorrhage (6·5 versus 5·6 per cent respectively; odds ratio (OR) 1·18, 95 per cent c.i. 0·38 to 3·62), intraoperative transfusion (23·4 versus 23·7 per cent; OR 0·98, 0·51 to 1·87), overall haemorrhage (10·2 versus 12·0 per cent; OR 0·83, 0·35 to 1·94), CCI score (24 versus 28; P = 0·520), major complications (23·1 versus 13·9 per cent; OR 1·82, 0·92 to 3·79) and 90-day mortality (5·6 versus 4·6 per cent; OR 1·21, 0·36 to 4·09). CONCLUSION: This observational study suggested that aspirin continuation is not associated with a higher rate of bleeding-related complications after elective hepatic surgery.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille
CNRS

Collections :

Équipe(s) de recherche :

Innovation/évaluation des médicaments injectables

Date de dépôt :

2019-02-26T17:06:58Z

Use of aspirin and bleeding-related ... BibTeX CSV Excel RIS

Use of aspirin and bleeding-related ...

BibTeX

CSV

Excel

RIS