Titre :

Broadening and enhancing bacteriocins activities by association with bioactive substances

Auteur(s) :

Zgheib, Hassan [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
BioEcoAgro - UMR transfrontalière INRAe - UMRT1158
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Drider, Djamel [Auteur]
BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s)
Belguesmia, Yanath [Auteur]
BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s)

Titre de la revue :

International Journal of Environmental Research and Public Health

Pagination :

7835

Éditeur :

MDPI

Date de publication :

2020-10-26

ISSN :

1661-7827

Mot(s)-clé(s) en anglais :

bacteriocin
synergism
antibiotics
nanoparticles
phages
essential oils
antiviral
anticancer
antibiofilm

Discipline(s) HAL :

Sciences de l'ingénieur [physics]

Résumé en anglais : [en]

Bacteriocins are antimicrobial peptides some of which are endowed with antiviral, anticancer and antibiofilm properties. These properties could be improved through synergistic interactions of these bacteriocins with other ...
Lire la suite >Bacteriocins are antimicrobial peptides some of which are endowed with antiviral, anticancer and antibiofilm properties. These properties could be improved through synergistic interactions of these bacteriocins with other bioactive molecules such as antibiotics, phages, nanoparticles and essential oils. A number of studies are steadily reporting the effects of these combinations as new and potential therapeutic strategies in the future, as they may offer many incentives over existing therapies. In particular, bacteriocins can benefit from combination with nanoparticles which can improve their stability and solubility, and protect them from enzymatic degradation, reduce their interactions with other molecules and improve their bioavailability. Furthermore, the combination of bacteriocins with other antimicrobials is foreseen as a way to reduce the development of antibiotic resistance due to the involvement of several modes of action. Another relevant advantage of these synergistic combinations is that it decreases the concentration of each antimicrobial component, thereby reducing their side effects such as their toxicity. In addition, combination can extend the utility of bacteriocins as antiviral or anticancer agents. Thus, in this review, we report and discuss the synergistic effects of bacteriocin combinations as medicines, and also for other diverse applications including, antiviral, antispoilage, anticancer and antibiofilms.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL