Patterns and predictors of skin score ...
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Article dans une revue scientifique
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Title :
Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study.
Author(s) :
Herrick, Ariane L. [Auteur]
University of Manchester [Manchester]
Peytrignet, Sebastien [Auteur]
University of Manchester [Manchester]
Lunt, Mark [Auteur]
University of Manchester [Manchester]
Pan, Xiaoyan [Auteur]
University of Manchester [Manchester]
Hesselstrand, Roger [Auteur]
Skane University Hospital [Lund]
Mouthon, Luc [Auteur]
Hôpital Cochin [AP-HP]
Silman, Alan [Auteur]
University of Oxford
Dinsdale, Graham [Auteur]
University of Manchester [Manchester]
Brown, Edith [Auteur]
University of Manchester [Manchester]
Czirjak, Laszlo [Auteur]
University of Pecs
Distler, Jorg [Auteur]
Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg [FAU]
Distler, Oliver [Auteur]
University hospital of Zurich [Zurich]
Fligelstone, Kim [Auteur]
NHS Foundation Trust [London]
Ochiel, Rachel [Auteur]
NHS Foundation Trust [London]
Vonk, Madelon [Auteur]
Radboud University Medical Center [Nijmegen]
Ancuta, Codrina [Auteur]
University of Medicine and Pharmacy "Grigore T.Popa" Iasi [UMF lasi]
Ong, Voon H. [Auteur]
Farge, Dominique [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hudson, Marie [Auteur]
McGill University = Université McGill [Montréal, Canada]
Matucci-Cerinic, Marco [Auteur]
Università degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
Balbir-Gurman, Alexandra [Auteur]
Rappaport faculty of Medicine
Midtvedt, Oyvind [Auteur]
Oslo University Hospital [Oslo]
Jobanputra, Paresh [Auteur]
Jordan, Alison C. [Auteur]
Stevens, Wendy [Auteur]
St Vincent's University Hospital
Moinzadeh, Pia [Auteur]
University Hospital of Cologne [Cologne]
Hall, Frances C. [Auteur]
Agard, Christian [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Anderson, Marina E. [Auteur]
University of Liverpool
Diot, Elisabeth [Auteur]
Hôpital Bretonneau
Madhok, Rajan [Auteur]
Glasgow Royal Infirmary
Akil, Mohammed [Auteur]
Buch, Maya H. [Auteur]
Leeds Teaching Hospitals NHS Trust
Chung, Lorinda [Auteur]
Damjanov, Nemanja S. [Auteur]
University of Belgrade [Belgrade]
Gunawardena, Harsha [Auteur]
North Bristol NHS Trust [Bristol, UK]
Lanyon, Peter [Auteur]
Ahmad, Yasmeen [Auteur]
Chakravarty, Kuntal [Auteur]
Jacobsen, Soren [Auteur]
Rigshospitalet [Copenhagen]
Macgregor, Alexander J. [Auteur]
University of East Anglia [Norwich] [UEA]
Mchugh, Neil [Auteur]
University of Bath [Bath]
Muller-Ladner, Ulf [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Riemekasten, Gabriela [Auteur]
Universität zu Lübeck = University of Lübeck [Lübeck]
Becker, Michael [Auteur]
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Roddy, Janet [Auteur]
Royal Perth Hospital
Carreira, Patricia [Auteur]
Hospital Universitario 12 de Octubre [Madrid]
Fauchais, Anne-Laure [Auteur]
Service de Médecine interne A et polyclinique médicale [CHU Limoges]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hamilton, Jennifer [Auteur]
Inanc, Murat [Auteur]
Istanbul University
Mclaren, John S. [Auteur]
Van Laar, J. M. [Auteur]
Universiteit Utrecht / Utrecht University [Utrecht]
Pathare, Sanjay [Auteur]
Proudman, Susanna [Auteur]
University of Adelaide
Rudin, Anna [Auteur]
Sahlgrenska Academy at University of Gothenburg [Göteborg]
Sahhar, Joanne [Auteur]
Monash University [Melbourne]
Coppere, Brigitte [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Serratrice, Christine [Auteur]
Hôpital Saint-Joseph [Marseille]
Sheeran, Tom [Auteur]
Veale, Douglas J. [Auteur]
St Vincent's University Hospital
Grange, Claire [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Trad, Georges-Selim [Auteur]
Hôpital Ambroise Paré [AP-HP]
Denton, Christopher [Auteur]
University College of London [London] [UCL]
University of Manchester [Manchester]
Peytrignet, Sebastien [Auteur]
University of Manchester [Manchester]
Lunt, Mark [Auteur]
University of Manchester [Manchester]
Pan, Xiaoyan [Auteur]
University of Manchester [Manchester]
Hesselstrand, Roger [Auteur]
Skane University Hospital [Lund]
Mouthon, Luc [Auteur]
Hôpital Cochin [AP-HP]
Silman, Alan [Auteur]
University of Oxford
Dinsdale, Graham [Auteur]
University of Manchester [Manchester]
Brown, Edith [Auteur]
University of Manchester [Manchester]
Czirjak, Laszlo [Auteur]
University of Pecs
Distler, Jorg [Auteur]
Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg [FAU]
Distler, Oliver [Auteur]
University hospital of Zurich [Zurich]
Fligelstone, Kim [Auteur]
NHS Foundation Trust [London]
Ochiel, Rachel [Auteur]
NHS Foundation Trust [London]
Vonk, Madelon [Auteur]
Radboud University Medical Center [Nijmegen]
Ancuta, Codrina [Auteur]
University of Medicine and Pharmacy "Grigore T.Popa" Iasi [UMF lasi]
Ong, Voon H. [Auteur]
Farge, Dominique [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hudson, Marie [Auteur]
McGill University = Université McGill [Montréal, Canada]
Matucci-Cerinic, Marco [Auteur]
Università degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
Balbir-Gurman, Alexandra [Auteur]
Rappaport faculty of Medicine
Midtvedt, Oyvind [Auteur]
Oslo University Hospital [Oslo]
Jobanputra, Paresh [Auteur]
Jordan, Alison C. [Auteur]
Stevens, Wendy [Auteur]
St Vincent's University Hospital
Moinzadeh, Pia [Auteur]
University Hospital of Cologne [Cologne]
Hall, Frances C. [Auteur]
Agard, Christian [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Anderson, Marina E. [Auteur]
University of Liverpool
Diot, Elisabeth [Auteur]
Hôpital Bretonneau
Madhok, Rajan [Auteur]
Glasgow Royal Infirmary
Akil, Mohammed [Auteur]
Buch, Maya H. [Auteur]
Leeds Teaching Hospitals NHS Trust
Chung, Lorinda [Auteur]
Damjanov, Nemanja S. [Auteur]
University of Belgrade [Belgrade]
Gunawardena, Harsha [Auteur]
North Bristol NHS Trust [Bristol, UK]
Lanyon, Peter [Auteur]
Ahmad, Yasmeen [Auteur]
Chakravarty, Kuntal [Auteur]
Jacobsen, Soren [Auteur]
Rigshospitalet [Copenhagen]
Macgregor, Alexander J. [Auteur]
University of East Anglia [Norwich] [UEA]
Mchugh, Neil [Auteur]
University of Bath [Bath]
Muller-Ladner, Ulf [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Riemekasten, Gabriela [Auteur]
Universität zu Lübeck = University of Lübeck [Lübeck]
Becker, Michael [Auteur]
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Roddy, Janet [Auteur]
Royal Perth Hospital
Carreira, Patricia [Auteur]
Hospital Universitario 12 de Octubre [Madrid]
Fauchais, Anne-Laure [Auteur]
Service de Médecine interne A et polyclinique médicale [CHU Limoges]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hamilton, Jennifer [Auteur]
Inanc, Murat [Auteur]
Istanbul University
Mclaren, John S. [Auteur]
Van Laar, J. M. [Auteur]
Universiteit Utrecht / Utrecht University [Utrecht]
Pathare, Sanjay [Auteur]
Proudman, Susanna [Auteur]
University of Adelaide
Rudin, Anna [Auteur]
Sahlgrenska Academy at University of Gothenburg [Göteborg]
Sahhar, Joanne [Auteur]
Monash University [Melbourne]
Coppere, Brigitte [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Serratrice, Christine [Auteur]
Hôpital Saint-Joseph [Marseille]
Sheeran, Tom [Auteur]
Veale, Douglas J. [Auteur]
St Vincent's University Hospital
Grange, Claire [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Trad, Georges-Selim [Auteur]
Hôpital Ambroise Paré [AP-HP]
Denton, Christopher [Auteur]
University College of London [London] [UCL]
Journal title :
Annals of the Rheumatic Diseases
Abbreviated title :
Ann. Rheum. Dis.
Volume number :
77
Pages :
563–570
Publication date :
2018-01-06
ISSN :
1468-2060
Keyword(s) :
outcomes research
autoantibodies
systemic sclerosis
autoantibodies
systemic sclerosis
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive ...
Show more >Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs). Methods The modified Rodnan skin score (mRSS) was recorded every 3 months in 326 patients. ‘Progressors’ were defined as those experiencing a 5-unit and 25% increase in mRSS score over 12 months (±3 months). Logistic models were fitted to predict progression and, using receiver operating characteristic (ROC) curves, were compared on the basis of the area under curve (AUC), accuracy and positive predictive value (PPV). Results 66 patients (22.5%) progressed, 227 (77.5%) did not (33 could not have their status assessed due to insufficient data). Progressors had shorter disease duration (median 8.1 vs 12.6 months, P=0.001) and lower mRSS (median 19 vs 21 units, P=0.030) than non-progressors. Skin score was highest, and peaked earliest, in the anti-RNA polymerase III (Pol3+) subgroup (n=50). A first predictive model (including mRSS, duration of skin thickening and their interaction) had an accuracy of 60.9%, AUC of 0.666 and PPV of 33.8%. By adding a variable for Pol3 positivity, the model reached an accuracy of 71%, AUC of 0.711 and PPV of 41%. Conclusions Two prediction models for progressive skin thickening were derived, for use both in clinical practice and for cohort enrichment in RCTs. These models will inform recruitment into the many clinical trials of dcSSc projected for the coming years.Show less >
Show more >Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs). Methods The modified Rodnan skin score (mRSS) was recorded every 3 months in 326 patients. ‘Progressors’ were defined as those experiencing a 5-unit and 25% increase in mRSS score over 12 months (±3 months). Logistic models were fitted to predict progression and, using receiver operating characteristic (ROC) curves, were compared on the basis of the area under curve (AUC), accuracy and positive predictive value (PPV). Results 66 patients (22.5%) progressed, 227 (77.5%) did not (33 could not have their status assessed due to insufficient data). Progressors had shorter disease duration (median 8.1 vs 12.6 months, P=0.001) and lower mRSS (median 19 vs 21 units, P=0.030) than non-progressors. Skin score was highest, and peaked earliest, in the anti-RNA polymerase III (Pol3+) subgroup (n=50). A first predictive model (including mRSS, duration of skin thickening and their interaction) had an accuracy of 60.9%, AUC of 0.666 and PPV of 33.8%. By adding a variable for Pol3 positivity, the model reached an accuracy of 71%, AUC of 0.711 and PPV of 41%. Conclusions Two prediction models for progressive skin thickening were derived, for use both in clinical practice and for cohort enrichment in RCTs. These models will inform recruitment into the many clinical trials of dcSSc projected for the coming years.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Research team(s) :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Submission date :
2019-03-01T14:46:30Z
2024-01-19T13:37:51Z
2024-01-19T13:37:51Z
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