Titre :

Top-down approaches for the study of single-cells : micro-engineering and electrical phenotype

Auteur(s) :

SENEZ, Vincent [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Akalin, Tahsin [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Arscott, Steve [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
BOURZGUI, Nour-Eddine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Bocquet, Bertrand [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Fujii, Teruo [Auteur]
Lennon, Erwan [Auteur]
Yamamoto, Takahisa [Auteur]

Titre de la revue :

Advances in Science and Technology

Pagination :

97-106

Éditeur :

Trans Tech Publications

Date de publication :

2006

Discipline(s) HAL :

Sciences de l'ingénieur [physics]

Résumé en anglais : [en]

Single-cell analysis is a very important field of research and is currently at the frontier of physical and biological sciences. Understanding how the phenotype of a single-cell arises from its genotype is a complex topic. ...
Lire la suite >Single-cell analysis is a very important field of research and is currently at the frontier of physical and biological sciences. Understanding how the phenotype of a single-cell arises from its genotype is a complex topic. Currently, the prevailing paradigm to analyze cellular functions is the study of biochemical interactions using fluorescence based imaging systems. However, the elimination of the labelling process is highly desirable to improve the accuracy of the analysis. Living cells are electromagnetic units; in as much they use electric mechanisms to control and regulate dynamic processes involved in inter alia signal transduction, metabolism, proliferation and differentiation. Recent developments in micro- and nanofabrication technologies are offering great opportunities for the analysis of single cells; the combination of micro fluidic environments, nano electrodes/wires and ultra wide band electromagnetic engineering will soon make possible the investigation of local (submicrometer scale) dynamic processes integrating several events at different time scales. In the paper, we present recent approaches which aim at investigating singlecells with the help of MEMS and NEMS (Micro and Nano Electro Mechanical Systems) and ultra wide band (DC-THz) electromagnetic characterization techniquesLire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL