Titre :

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis

Auteur(s) :

Saroha, Ashish [Auteur]
Weizmann Institute of Science [Rehovot, Israël]
Pewzner-Jung, Yael [Auteur]
Weizmann Institute of Science [Rehovot, Israël]
Ferreira, Natalia [Auteur]
Weizmann Institute of Science [Rehovot, Israël]
Sharma, Piyush [Auteur]

Jouan, Youenn [Auteur]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
Kelly, Samuel [Auteur]
Georgia Institute of Technology [Atlanta]
Feldmesser, Ester [Auteur]
Weizmann Institute of Science [Rehovot, Israël]
Merrill, Alfred [Auteur]
Georgia Institute of Technology [Atlanta]
Trottein, François [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Paget, Christophe [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
Lang, Karl [Auteur]

Futerman, Anthony [Auteur]
Weizmann Institute of Science [Rehovot, Israël]

Titre de la revue :

FRONTIERS IN IMMUNOLOGY

Éditeur :

Frontiers

Date de publication :

2017-11-01

ISSN :

1664-3224

Mot(s)-clé(s) en anglais :

ceramide synthase 2
glycosphingolipids
invariant natural killer T cells
liver
lymphocytic choriomeningitis virus
thymus
very-long chain ceramides

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological ...
Lire la suite >The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs appears particularly critical in determining SL function. Here, we show a role for very-long acyl chain SLs (VLC-SLs) in invariant natural killer T (iNKT) cell maturation in the thymus and homeostasis in the liver. Ceramide synthase 2-null mice, which lack VLC-SLs, were susceptible to a hepatotropic strain of lymphocytic choriomeningitis virus, which is due to a reduction in the number of iNKT cells. Bone marrow chimera experiments indicated that hematopoietic-derived VLC-SLs are essential for maturation of iNKT cells in the thymus, whereas parenchymal-derived VLC-SLs are crucial for iNKT cell survival and maintenance in the liver. Our findings suggest a critical role for VLC-SL in iNKT cell physiology.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Date de dépôt :

2021-10-09T01:30:40Z