Cyclodextrins based delivery systems for macro biomolecules

Liu, Jiang; Ding, Xin; Fu, Yupeng; Xiang, Cen; Yuan, Yuan; Zhang, Yongmin; Yu, Peng

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.ejmech.2020.113105

Permalink :

http://hdl.handle.net/20.500.12210/57169

Title :

Cyclodextrins based delivery systems for macro biomolecules

Author(s) :

Liu, Jiang [Auteur]
Institut Parisien de Chimie Moléculaire [IPCM]
Ding, Xin [Auteur]
Tianjin University of Science and Technology [TUST]
Fu, Yupeng [Auteur]
Institut Parisien de Chimie Moléculaire [IPCM]
Xiang, Cen [Auteur]
Tianjin University of Science and Technology [TUST]
Yuan, Yuan [Auteur]
Integrated Optimization with Complex Structure [INOCS]
Zhang, Yongmin [Auteur]
Institut Parisien de Chimie Moléculaire [IPCM]
Yu, Peng [Auteur]
Tianjin University of Science and Technology [TUST]

Journal title :

European Journal of Medicinal Chemistry

Pages :

113105

Publisher :

Elsevier

Publication date :

2021-02

ISSN :

0223-5234

English keyword(s) :

Cyclodextrins
Drug delivery systems
Proteins
Nucleic acids
Particles

HAL domain(s) :

Sciences du Vivant [q-bio]/Microbiologie et Parasitologie

English abstract : [en]

Macro biomolecules are of vital importance in regulating the biofunctions in organisms, in which proteins (including peptides when mentioned below) and nucleic acids (NAs) are the most important. Therefore, these proteins ...
Show more >Macro biomolecules are of vital importance in regulating the biofunctions in organisms, in which proteins (including peptides when mentioned below) and nucleic acids (NAs) are the most important. Therefore, these proteins and NAs can be applied as “drugs” to regulate the biofunctions from abnormal to normal. Either for proteins and NAs, the most challenging thing is to avoid the biodegradation or physicochemical degradation before they reach the targeted location, and then functions as complete functional structures. Hence, appropriate delivery systems are very important which can protect them from these degradations. Cyclodextrins (CDs) based delivery systems achieved mega successes due to their outstanding pharmaceutical properties and there have been several reviews on CDs based small molecule drug delivery systems recently. But for biomolecules, which are getting more and more important for modern therapies, however, there are very few reviews to systematically summarize and analyze the CDs-based macro biomolecules delivery systems, especially for proteins. In this review, there were some of the notable examples were summarized for the macro biomolecules (proteins and NAs) delivery based on CDs. For proteins, this review included insulin, lysozyme, bovine serum albumin (BSA), green fluorescent protein (GFP) and IgG’s, etc. deliveries in slow release, stimulating responsive release or targeting release manners. For NAs, this review summarized cationic CD-polymers and CD-cluster monomers as NAs carriers, notably, including the multicomponents targeting CD-based carriers and the virus-like RNA assembly method siRNA carriers.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL

Submission date :

2021-11-13T02:59:13Z

Files

https://hal.sorbonne-universite.fr/hal-03102094/document
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