Title :

Tau Stabilizes Chromatin Compaction

Author(s) :

Rico, Thomas [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Gilles, Melissa [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Chauderlier, Alban [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Comptdaer, Thomas [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Magnez, Romain [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Chwastyniak, Maggy [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Drobecq, Herve [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
PINET, FLORENCE [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Thuru, Xavier [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Buee, Luc [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Galas, Marie-Christine [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lefebvre, Bruno [Auteur correspondant]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Journal title :

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Pages :

740550

Publisher :

Frontiers media

Publication date :

2021-10-14

ISSN :

2296-634X

English keyword(s) :

Tau protein (Tau)
chromatin remodeling
chromatin regulation
histone modification and chromatin structure
histone deacetylase inhibitor (HDAC inhibitor)
histone (de)acetylation
cancer biology

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes ...
Show more >An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive. Here we report that Tau expression in breast cancer cell lines causes resistance to the anti-cancer effects of histone deacetylase inhibitors, by preventing histone deacetylase inhibitor-inducible gene expression and remodeling of chromatin structure. We identify Tau as a protein recognizing and binding to core histone when H3 and H4 are devoid of any post-translational modifications or acetylated H4 that increases the Tau’s affinity. Consistent with chromatin structure alterations in neurons found in frontotemporal lobar degeneration, Tau mutations did not prevent histone deacetylase-inhibitor-induced higher chromatin structure remodeling by suppressing Tau binding to histones. In addition, we demonstrate that the interaction between Tau and histones prevents further histone H3 post-translational modifications induced by histone deacetylase-inhibitor treatment by maintaining a more compact chromatin structure. Altogether, these results highlight a new cellular role for Tau as a chromatin reader, which opens new therapeutic avenues to exploit Tau biology in neuronal and cancer cells.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Développement de stratégies innovantes pour une approche transdisciplinaire de la maladie d'Alzheime

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL