Title :

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

Author(s) :

Pagliazzo, Lucile [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Caby, Stéphanie [Auteur]
Institut Pasteur de Lille
Lancelot, Julien [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Salomé-Desnoulez, Sophie [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Saliou, Jean-Michel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Heimburg, Tino [Auteur]
Martin-Luther-Universität Halle Wittenberg [MLU]
Chassat, Thierry [Auteur]
Institut Pasteur de Lille
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Sippl, Wolfgang [Auteur]
Martin-Luther-Universität Halle Wittenberg [MLU]
Vicogne, Jérôme [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pierce, Raymond [Auteur]

Journal title :

PLOS Neglected Tropical Diseases

Pages :

e0009503

Publisher :

Public Library of Science

Publication date :

2021-11-29

ISSN :

1935-2727

HAL domain(s) :

Sciences du Vivant [q-bio]/Biologie animale

English abstract : [en]

Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has elicited considerable interestas a target for drug discovery. Invalidation of its transcripts by RNAi leads to impaired survivalof the worms in infected mice and its ...
Show more >Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has elicited considerable interestas a target for drug discovery. Invalidation of its transcripts by RNAi leads to impaired survivalof the worms in infected mice and its inhibition causes cell apoptosis and death. Todetermine why it is a promising therapeutic target the study of the currently unknown cellularsignaling pathways involving this enzyme is essential. Protein partners of SmHDAC8 werepreviously identified by yeast two-hybrid (Y2H) cDNA library screening and by mass spectrometry(MS) analysis. Among these partners we characterized SmRho1, the schistosomeorthologue of human RhoA GTPase, which is involved in the regulation of the cytoskeleton.In this work, we validated the interaction between SmHDAC8 and SmRho1 and exploredthe role of the lysine deacetylase in cytoskeletal regulation.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL