Outdoor air pollution, exhaled 8-isoprostane ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the egea study
Auteur(s) :
Havet, Anais [Auteur]
Zerimech, Farid [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sanchez, Margaux [Auteur]
Siroux, Valerie [Auteur]
Le Moual, Nicole [Auteur]
Brunekreef, Bert [Auteur]
Stempfelet, Morgane [Auteur]
Kunzli, Nino [Auteur]
Jacquemin, Benedicte [Auteur]
Matran, Regis [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Nadif, Rachel [Auteur]
Zerimech, Farid [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sanchez, Margaux [Auteur]
Siroux, Valerie [Auteur]
Le Moual, Nicole [Auteur]
Brunekreef, Bert [Auteur]
Stempfelet, Morgane [Auteur]
Kunzli, Nino [Auteur]
Jacquemin, Benedicte [Auteur]
Matran, Regis [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Nadif, Rachel [Auteur]
Titre de la revue :
European Respiratory Journal
Nom court de la revue :
Eur. Respir. J.
Numéro :
51
Éditeur :
European Respiratory Society (ERS)
Date de publication :
2018-04-01
ISSN :
1399-3003
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
Résumé en anglais : [en]
Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor ...
Lire la suite >Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso. Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case–control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence. The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00–1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27–3.29) per 10 µg·m−3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06–2.12) per 1 pg·mL−1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005–0.46) per 5 µg·m−3), and decreased with O3 and O3-summer exposures (aβ −0.20 (95% CI −0.39– −0.01) and aβ −0.52 (95% CI −0.77– −0.26) per 10 µg·m−3, respectively). Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.Lire moins >
Lire la suite >Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso. Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case–control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence. The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00–1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27–3.29) per 10 µg·m−3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06–2.12) per 1 pg·mL−1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005–0.46) per 5 µg·m−3), and decreased with O3 and O3-summer exposures (aβ −0.20 (95% CI −0.39– −0.01) and aβ −0.52 (95% CI −0.77– −0.26) per 10 µg·m−3, respectively). Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Projet Européen :
Établissement(s) :
CHU Lille
Institut Pasteur de Lille
Université de Lille
Institut Pasteur de Lille
Université de Lille
Date de dépôt :
2022-02-02T10:23:19Z
2022-11-30T08:29:11Z
2022-11-30T08:29:11Z
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